Evidence map›Paper›PMID 35946312›Full record

ArticleOpen biology2022

A genetic model for

Rui Yang, Amanda S Meyer, Ilia A Droujinine, Namrata D Udeshi, Yanhui Hu, Jinjin Guo, Jill A McMahon, Dominique K Carey, Charles Xu, Qiao Fang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Cell-death induced immune response and coagulopathy promote cachexia inbioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Cancers · 2025
    Review
  15. Review
  16. Tissue-Specific Biotinylation for Interorgan Communication.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Rui YangDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2291-4914
Amanda S MeyerDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1022-6137
Ilia A DroujinineDepartment of Molecular Medicine, Scripps Research, La Jolla, CA, USA.ORCID 0000-0003-1311-4392
Namrata D UdeshiBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Jinjin GuoDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA.
Jill A McMahonDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA.
Dominique K CareyBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Charles XuBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Qiao FangDepartment of Molecular Genetics, University of Toronto, Toronto, ON Canada, M5S 3E1.
Jihui ShaDepartment of Biological Chemistry, Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA.
Shishang QinBIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, People's Republic of China.
David RoccoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
James WohlschlegelDepartment of Biological Chemistry, Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA.
Alice Y TingChan Zuckerberg Biohub, San Francisco, CA, USA.
Steven A CarrBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-3779-1729
University of Southern California · USBroad Institute · USHarvard University · USUniversity of California, Los Angeles · USChan Zuckerberg Initiative (United States) · USHoward Hughes Medical Institute · USPeking University · CNScripps Institution of Oceanography · USUniversity of Toronto · CA

Funding

Mapping protein communication between organs in homeostasis and diseaseR01DK121409 · NIDDK · HARVARD MEDICAL SCHOOL · PI CARR, STEVEN A, MCMAHON, ANDREW P. · 2018 to 2022
$8.3M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Howard Hughes Medical InstituteNIDDK NIH HHS R01 DK121409NIGMS NIH HHS R01 GM089778
6 · The paper itself

Abstract

Organ functions are highly specialized and interdependent. Secreted factors regulate organ development and mediate homeostasis through serum trafficking and inter-organ communication. Enzyme-catalysed proximity labelling enables the identification of proteins within a specific cellular compartment. Here, we report a

Indexed as

Models, GeneticSecretomeAnimalsBiotinylationMammalsMass SpectrometryMiceProteomicsBirAinter-organ communicationproximity-labellingsecretomeserum proteinsTurboID

Identifiers

PMID35946312
PMCPMC9364151
OpenAlexW4291021353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.