ArticleAsian journal of andrology
Genetically predicted insomnia causally increases the risk of erectile dysfunction.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Review of Mendelian randomization studies on common male-specific diseases.Frontiers in endocrinology · 2025Pooled it
- Insomnia in relation to 10 urological and reproductive conditions: a two-sample Mendelian randomization study.Translational andrology and urology · 2025Article
- A proteome-wide association study reveals novel plasma proteins as potential therapeutic targets for metabolic dysfunction-associated steatotic liver disease.Frontiers in endocrinology · 2025Article
- Causal relationship between sleep traits and erectile dysfunction: evidence from Mendelian randomization analysis.Archives of medical science : AMS · 2025Article
- The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study.Sexual medicine · 2024Article
- Dietary intakes of vitamin BTranslational andrology and urology · 2024Article
- Article
- Inflammatory proteins mediate male erectile dysfunction via plasma metabolites.Sexual medicine · 2024Article
- Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian Randomization study.Journal of advanced research · 2024Article
- Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study.Frontiers in public health · 2024Article
- Genetically predicted major depression causally increases the risk of temporomandibular joint disorders.Frontiers in genetics · 2024Article
- Serum 25-hydroxyvitamin D level and erectile dysfunction: a causal relationship? Findings from a two-sample Mendelian randomization study.Frontiers in molecular biosciences · 2024Article
- Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample mendelian randomization study.BMC urology · 2023Article
- Genetic Insights into Intestinal Microbiota and Risk of Infertility: A Mendelian Randomization Study.Microorganisms · 2023Article
- Effects of major depression and bipolar disorder on erectile dysfunction: a two-sample mendelian randomization study.BMC medical genomics · 2023Article
- Depression and risk of sarcopenia: a national cohort and Mendelian randomization study.Frontiers in psychiatry · 2023Article
- Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Potential causal association between aspirin use and erectile dysfunction in European population: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Genetic insights into the risk of snoring on stroke and ischemic stroke: A single-variable and multivariable Mendelian randomization.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep has attracted extensive attention due to its significance in health. However, its association with erectile dysfunction (ED) is insufficiently investigated. To investigate the potential causal links between sleep traits (insomnia, sleep duration, and chronotype) and ED, this study was performed. The single-nucleotide polymorphisms (SNPs) associated with insomnia, sleep duration, and chronotype were retrieved from previous genome-wide association studies (GWAS). A conventional two-sample Mendelian randomization (MR) was used to estimate the causal links between sleep traits and ED. The summary statistics of ED were from individuals of European ancestry (6175 cases vs 217 630 controls). As shown by the random effect inverse-variance-weighting (IVW) estimator, genetically predicted insomnia was causally associated with a 1.15-fold risk of ED (95% confidence interval: 1.07-1.23, P < 0.001). Sleep duration and morningness were not causally associated with ED, as indicated by the IVW (all P > 0.05). These findings were consistent with the results of sensitivity analyses. Based on genetic data, this study provides causal evidence that genetically predicted insomnia increases the risk of ED, whereas sleep duration and chronotype do not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.