Evidence map›Paper›PMID 35946068›Full record

ArticleBJPsych open2022

Efficacy and moderators of cognitive therapy versus behavioural activation for adults with depression: study protocol of a systematic review and meta-analysis of individual participant data.

Ellen Driessen, Zachary D Cohen, Lorenzo Lorenzo-Luaces, Steven D Hollon, David A Richards, Keith S Dobson, Sona Dimidjian, Jaime Delgadillo, Fernando L Vázquez, Kathleen McNamara and 7 more

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In one paragraph

Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ellen DriessenDepartment of Clinical Psychology, Behavioural Science Institute, Radboud University, The Netherlands; and Depression Expertise Center, Pro Persona Mental Health Care, The Netherlands.ORCID https://orcid.org/0000-0002-9602-1548
Zachary D CohenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA.ORCID https://orcid.org/0000-0002-4883-1028
Lorenzo Lorenzo-LuacesDepartment of Psychological and Brain Sciences, Indiana University Bloomington, USA.
Steven D HollonDepartment of Psychology, Vanderbilt University, USA.
David A RichardsDepartment of Health and Community Science, Faculty of Health and Life Sciences, University of Exeter, UK; and Department of Health and Caring Sciences, Western Norway University of Applied Sciences, Norway.
Keith S DobsonDepartment of Psychology, University of Calgary, Canada.
Sona DimidjianCrown Institute and Department of Psychology and Neuroscience, University of Colorado Boulder, USA.
Jaime DelgadilloClinical and Applied Psychology Unit, University of Sheffield, UK.
Fernando L VázquezDepartment of Clinical Psychology and Psychobiology, University of Santiago de Compostela, Spain.
Kathleen McNamaraPrivate Practice, Colorado, USA.
John J HoranCounseling Psychology Program, Arizona State University, USA.
Pauline GardnerCaulfield Pain Management and Research Centre, Caulfield Hospital, Australia.
Tian P OeiSchool of Psychology, The University of Queensland, Australia.
Anuj H P MehtaDepartment of Psychology, University of Toronto Scarborough, Canada.
Jos W R TwiskDepartment of Epidemiology and Biostatistics, Amsterdam University Medical Centers, The Netherlands.
Ioana A CristeaDepartment of Brain and Behavioral Sciences, University of Pavia; and IRCCS Mondino Foundation, Italy.ORCID https://orcid.org/0000-0002-9854-7076
Pim CuijpersDepartment of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-5497-2743

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Translating Measures of Visual Experience to Children with Autism and Down SyndromeKL2TR002530 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI ROBB, SHERI L · 2018 to 2022
$4.8M
NCATS NIH HHS KL2 TR002530NCATS NIH HHS UL1 TR002529NCATS NIH HHS UL1TR002529Nederlandse Organisatie voor Wetenschappelijk Onderzoek 016.Veni.195.215 6806NIH HHS KL2TR002530
6 · The paper itself

Abstract

backgroundCognitive therapy and behavioural activation are both widely applied and effective psychotherapies for depression, but it is unclear which works best for whom. Individual participant data (IPD) meta-analysis allows for examining moderators at the participant level and can provide more precise effect estimates than conventional meta-analysis, which is based on study-level data.

aimsThis article describes the protocol for a systematic review and IPD meta-analysis that aims to compare the efficacy of cognitive therapy and behavioural activation for adults with depression, and to explore moderators of treatment effect. (PROSPERO: CRD42022341602).

methodSystematic literature searches will be conducted in PubMed, PsycINFO, EMBASE and the Cochrane Library, to identify randomised clinical trials comparing cognitive therapy and behavioural activation for adult acute-phase depression. Investigators of these trials will be invited to share their participant-level data. One-stage IPD meta-analyses will be conducted with mixed-effects models to assess treatment effects and to examine various available demographic, clinical and psychological participant characteristics as potential moderators. The primary outcome measure will be depressive symptom level at treatment completion. Secondary outcomes will include post-treatment anxiety, interpersonal functioning and quality of life, as well as follow-up outcomes.

conclusionsTo the best of our knowledge, this will be the first IPD meta-analysis concerning cognitive therapy versus behavioural activation for adult depression. This study has the potential to enhance our knowledge of depression treatment by using state-of-the-art statistical techniques to compare the efficacy of two widely used psychotherapies, and by shedding more light on which of these treatments might work best for whom.

Indexed as

behavioural activationcognitive–behavioural therapiesDepressive disordersindividual participant data meta-analysismoderators

Identifiers

PMID35946068
PMCPMC9379999

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.