ArticleJournal of biomedical optics2022
Precision of attenuation coefficient measurements by optical coherence tomography.
Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography.Journal of biophotonics · 2025Article
- Accurate attenuation characterization in optical coherence tomography using multi-reference phantoms and deep learning.Biomedical optics express · 2024Article
- Accuracy and precision of depth-resolved estimation of attenuation coefficients in optical coherence tomography.Journal of biomedical optics · 2023Article
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3 authors.
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Abstract
significanceOptical coherence tomography (OCT) is an interferometric imaging modality, which provides tomographic information on the microscopic scale. Furthermore, OCT signal analysis facilitates quantification of tissue optical properties (e.g., the attenuation coefficient), which provides information regarding the structure and organization of tissue. However, a rigorous and standardized measure of the precision of the OCT-derived optical properties, to date, is missing.
aimWe present a robust theoretical framework, which provides the Cramér -Rao lower bound σμOCT for the precision of OCT-derived optical attenuation coefficients. APPROACH: Using a maximum likelihood approach and Fisher information, we derive an analytical solution for σμOCT when the position and depth of focus are known. We validate this solution, using simulated OCT signals, for which attenuation coefficients are extracted using a least-squares fitting procedure.
resultsOur analytical solution is in perfect agreement with simulated data without shot noise. When shot noise is present, we show that the analytical solution still holds for signal-to-noise ratios (SNRs) in the fitting window being above 20 dB. For other cases (SNR<20 dB, focus position not precisely known), we show that the numerical calculation of the precision agrees with the σμOCT derived from simulated signals.
conclusionsOur analytical solution provides a fast, rigorous, and easy-to-use measure for OCT-derived attenuation coefficients for signals above 20 dB. The effect of uncertainties in the focal point position on the precision in the attenuation coefficient, the second assumption underlying our analytical solution, is also investigated by numerical calculation of the lower bounds. This method can be straightforwardly extended to uncertainty in other system parameters.
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