Evidence map›Paper›PMID 35945628›Full record

ArticleActa neuropathologica communications2022

Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology.

Adam Martersteck, Ivan Ayala, Daniel T Ohm, Callen Spencer, Christina Coventry, Sandra Weintraub, Eileen H Bigio, M -Marsel Mesulam, Changiz Geula, Emily Rogalski

Abstract readCase Reports
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Atypical Presentations of Alzheimer Disease.Continuum (Minneapolis, Minn.) · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam MartersteckMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA. acmarter@gmail.com.ORCID 0000-0001-6997-9390
Ivan AyalaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Daniel T OhmMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Callen SpencerMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Christina CoventryMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Eileen H BigioMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
M -Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.
Emily RogalskiMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.

Funding

Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROGALSKI, EMILY J · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SANDRA WEINTRAUB · 2021 to 2026
$26.3M
ASYMMETRIC NEURODEGENERATION AND LANGUAGE IN PRIMARY PROGRESSIVE APHASIAR01AG077444 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MAREK-MARSEL M MESULAM, EMILY J ROGALSKI · 2022 to 2026
$10.4M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Language in Primary Progressive AphasiaR01DC008552 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MESULAM, MAREK-MARSEL M · 2007 to 2021
$8.5M
Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical PhenotypeR01NS085770 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ · 2014 to 2024
$5.0M
Determinants of neurodegenerative decline in the aphasic variant of Alzheimer's diseaseR01AG056258 · NIA · UNIVERSITY OF CHICAGO · PI ROGALSKI, EMILY J · 2017 to 2022
$4.1M
Determinants of Neurodegenerative Decline in Primary Progressive AphasiaR01NS075075 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROGALSKI, EMILY J · 2012 to 2016
$1.7M
NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG056258NIA NIH HHS R01 AG077444NIA NIH HHS T32 AG020506NIDCD NIH HHS R01 DC008552NINDS NIH HHS R01 NS075075NINDS NIH HHS R01 NS085770
6 · The paper itself

Abstract

Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with Alzheimer disease neuropathologic change (ADNC). This study examined the quantitative relationship between regional binding of in vivo

Indexed as

Alzheimer DiseaseAphasia, Primary ProgressiveAmyloidAutopsyCarbolinesHumansMagnetic Resonance ImagingNeurofibrillary TanglesPlaque, AmyloidPositron-Emission Tomographytau ProteinsAmyloidCarbolinestau ProteinsAlzheimer diseaseAmyloidFlorbetapirFlortaucipirPositron emission tomographyPrimary progressive aphasiaStereologyTau

Identifiers

PMID35945628
PMCPMC9361632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.