Evidence map›Paper›PMID 35945477›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2022

Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age-results from the prospective COVIP study.

Georg Wolff, Bernhard Wernly, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Antonio Artigas, Bernardo Bollen Pinto, Joerg C Schefold, Malte Kelm, Stephan Binneboessel and 19 more

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04321265 (Outcomes and Prognostic Factors in Coronavirus Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04321265 unknown statusnot on this map

Outcomes and Prognostic Factors in Coronavirus Disease (COVID-19) in Very Old Intensive Care Patients

TypeobservationalSponsorHeinrich-Heine University, DuesseldorfRan2020 to 2023Enrolled1,500ConditionsCOVID-19, Elderly Patients, Critical Illness, Survival
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Sex-specific outcomes in COVID-19: missing pieces of the puzzle.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Article
  4. In reply: Sex-specific outcomes in COVID-19: missing pieces of the puzzle.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 19 institutions in 16 countries.

Georg WolffDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-1734-6177
Bernhard WernlyDepartment of Anaesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria.
Hans FlaattenDepartment of Clinical Medicine, Department of Anaesthesia and Intensive Care, Haukeland University Hospital, University of Bergen, Bergen, Norway.
Jesper FjølnerDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Raphael Romano BrunoDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
Antonio ArtigasDepartment of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain.
Bernardo Bollen PintoDepartment of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland.
Joerg C SchefoldDepartment of Intensive Care Medicine, Inselspital, Universitätsspital, University of Bern, Bern, Switzerland.
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
Stephan BinneboesselDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
Philipp BaldiaDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
Michael BeilDepartment of Medical Intensive Care, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Sigal SivriDepartment of Medical Intensive Care, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Peter Vernon van HeerdenDepartment of Anesthesia, Intensive Care and Pain Medicine, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Wojciech SzczeklikDepartment of Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland.
Muhammed ElhadiFaculty of Medicine, University of Tripoli, Tripoli, Libya.
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Sandra OeyenDepartment of Intensive Care 1K12IC, Ghent University Hospital, Ghent, Belgium.
Maria FlammInstitute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg, Austria.
Tilemachos ZafeiridisIntensive Care Unit General Hospital of Larissa, Larissa, Greece.
Brian MarshMater Misericordiae University Hospital, Dublin, Ireland.
Finn H AndersenDepartment of Anesthesia and Intensive Care, Ålesund Hospital, Ålesund, Norway.
Rui MorenoUnidade de Cuidados Intensivos Neurocríticos e Trauma, Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de Lisboa, Nova Médical School, Lisbon, Portugal.
Ariane BoumendilSorbonne Universités, UPMC Univ Paris, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe: épidémiologie hospitalière qualité et organisation des soins, Paris, France, Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Antoine, Service de Réanimation Médicale, Paris, France.
Dylan W De LangeDepartment of Intensive Care Medicine, University Medical Center, University Utrecht, Utrecht, The Netherlands.
Bertrand GuidetSorbonne Universités, UPMC Univ Paris, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe: épidémiologie hospitalière qualité et organisation des soins, Paris, France, Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Antoine, Service de Réanimation Médicale, Paris, France.
Susannah LeaverGeneral Intensive care, St George´s University Hospitals NHS Foundation Trust, London, UK.
Christian JungDepartment of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany. christian.jung@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0001-8325-250X
COVIP Study Group
Heinrich Heine University Düsseldorf · DEHebrew University of Jerusalem · ILParacelsus Medical University · ATSorbonne Université · FRAarhus University Hospital · DKGhent University Hospital · BEHaukeland University Hospital · NOHospital de São José · PTInnsbruck Medical University · ATJagiellonian University · PLMater Misericordiae University Hospital · IENorwegian University of Science and Technology · NOSt George’s University Hospitals NHS Foundation Trust · GBUniversitat Autònoma de Barcelona · ESUniversity Hospital of Geneva · CHUniversity Hospital of Larissa · GRUniversity Medical Center Utrecht · NLUniversity of Bern · CHUniversity of Tripoli · LY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOlder critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific differences in treatment and outcome after intensive care unit (ICU) admission in this cohort.

methodsWe performed a sex-specific analysis in critically ill patients ≥ 70 yr of age with COVID-19 who were included in the international prospective multicenter COVIP study. All patients were analyzed for ICU admission and treatment characteristics. We performed a multilevel adjusted regression analysis to elucidate associations of sex with 30-day mortality.

resultsA total of 3,159 patients (69.8% male, 30.2% female; median age, 75 yr) were included. Male patients were significantly fitter than female patients as determined by the Clinical Frailty Scale (fit, 67% vs 54%; vulnerable, 14% vs 19%; frail, 19% vs 27%; P < 0.001). Male patients more often underwent tracheostomy (20% vs 14%; odds ratio [OR], 1.57; P < 0.001), vasopressor therapy (69% vs 62%; OR, 1.25; P = 0.02), and renal replacement therapy (17% vs 11%; OR, 1.96; P < 0.001). There was no difference in mechanical ventilation, life-sustaining treatment limitations, and crude 30-day mortality (50% male vs 49% female; OR, 1.11; P = 0.19), which remained true after adjustment for disease severity, frailty, age and treatment limitations (OR, 1.17; 95% confidence interval, 0.94 to 1.45; P = 0.16).

conclusionIn this analysis of sex-specific treatment characteristics and 30-day mortality outcomes of critically ill patients with COVID-19 ≥ 70 yr of age, we found more tracheostomy and renal replacement therapy in male vs female patients, but no significant association of patient sex with 30-day mortality. STUDY REGISTRATION: www. CLINICALTRIALS: gov (NCT04321265); registered 25 March 2020).

Indexed as

COVID-19FrailtyAgedAged, 80 and overCritical IllnessFemaleHumansIntensive Care UnitsMalePandemicsProspective StudiesCOVIDCOVIPcritical illnesselderlymortalitysex

Identifiers

PMID35945477
PMCPMC9363137
OpenAlexW4291285546

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.