Evidence map›Paper›PMID 35945403›Full record

ArticleMolecular biology reports2022

Vasorin contributes to lung injury via FABP4-mediated inflammation.

Xiaoping Guo, Junming Sun, Jinning Liang, Siran Zhu, Mingyuan Zhang, Lichao Yang, Xuejing Huang, Kangning Xue, Zhongxiang Mo, Sha Wen and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Xiaoping GuoLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Junming SunLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Jinning LiangLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Siran ZhuCollege of Animal Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.
Mingyuan ZhangLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Lichao YangSchool of Public Health, Guangxi Medical University, Nanning, 530021, China.
Xuejing HuangLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Kangning XueLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Zhongxiang MoLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Sha WenLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Bing HuLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Jiajuan LiuLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Yiqiang OuyangLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China. 120535001@qq.com.
Min HeLaboratory Animal Center, Guangxi Medical University, Nanning, 530021, Guangxi, China. hemin@gxmu.edu.cn.ORCID http://orcid.org/0000-0002-2735-2474
Guangxi Medical University · CNGuangxi University · CN

Funding

Central Government Guides the Development of Local Science and Technology GUIKEZY1949025Central Government Guides the Development of Local Science and Technology GUIKEZY20198024
6 · The paper itself

Abstract

backgroundLung injury caused by pulmonary inflammation is one of the main manifestations of respiratory diseases. Vasorin (VASN) is a cell-surface glycoprotein encoded by the VASN gene and is expressed in the lungs of developing mouse foetuses. Previous research has revealed that VASN is associated with many diseases. However, its exact function in the lungs and the underlying mechanism remain poorly understood. METHODS AND

resultsTo investigate the molecular mechanisms involved in lung disease caused by VASN deficiency, a VASN gene knockout (VASN

conclusionsWe believe that these data provide molecular evidence for the regulatory role of VASN in inflammation in the context of lung injury.

Indexed as

Lung InjuryAnimalsApoptosis Regulatory ProteinsFatty Acid-Binding ProteinsInflammationInterleukin-6LungMembrane GlycoproteinsMembrane ProteinsMicePeroxisome Proliferator-Activated ReceptorsRNA, MessengerTumor Necrosis Factor-alphaApoptosis Regulatory ProteinsFabp4 protein, mouseFatty Acid-Binding ProteinsInterleukin-6Membrane GlycoproteinsMembrane ProteinsPeroxisome Proliferator-Activated ReceptorsRNA, MessengerTumor Necrosis Factor-alphaVasn protein, mouseFABP4InflammationLung injuryRNA sequencingVASN

Identifiers

PMID35945403
OpenAlexW4292438640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.