Observational studyJournal of neurology2022
Impact of delirium on the outcome of stroke: a prospective, observational, cohort study.
Observational study in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The associations of post-stroke delirium with outcomes: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Development of insomnia in patients with stroke: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Progress of nursing management for delirium in critically ill geriatric patients: a narrative review.Frontiers in human neuroscience · 2026Review
- Current practices in delirium prevention and treatment after acute stroke: results of a multicentre survey.Therapeutic advances in neurological disorders · 2026Article
- Association between stress hyperglycemia ratio and post-stroke delirium in critically ill patients with ischemic stroke: an MIMIC-IV database analysis.European journal of medical research · 2025Article
- Delirium as a mediating factor in the survival benefits of dexmedetomidine in acute brain injury management.Scientific reports · 2025Article
- The Association Between Possible Sarcopenia and Delirium Onset in Older Patients With Acute Stroke.Cureus · 2025Article
- Post-anesthesia care unit delirium in children with moyamoya disease undergoing indirect revascularization: incidence and risk factors.Korean journal of anesthesiology · 2025Article
- Is delirium after stroke associated with dysregulation of hypothalamic pituitary axis?Frontiers in stroke · 2025Article
- Post-stroke delirium is a predictor of prolonged hospital stay and poor functional outcome at 3 months.Frontiers in stroke · 2025Article
- Delirium following mechanical thrombectomy for ischemic stroke - individuals at risk, imaging biomarkers and prognosis.Frontiers in aging neuroscience · 2025Article
- Delirium is a Potential Predictor of Unfavorable Long-term Functional Outcomes in Patients with Acute Ischemic Stroke: A Prospective Observational Study.Journal of inflammation research · 2025Article
- Functional Outcomes After Decompressive Surgery in Patients with Malignant Space-Occupying Cerebellar Infarction.Neurology international · 2024Article
- Five-year stroke prognosis. Influence of post-stroke delirium and post-stroke dementia on mortality and disability (Research Study - Part of the PROPOLIS Study).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Management of delirium in acute stroke patients: a position paper by the Austrian Stroke Society on prevention, diagnosis, and treatment.Therapeutic advances in neurological disorders · 2024Review
- The Rehabilitation of Cognitive Impairment Following Stroke: A Commentary on a Systematic Review.British journal of neuroscience nursing · 2023Article
- Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship.Current neurology and neuroscience reports · 2022Review
- Impact of delirium on clinical outcomes in critically ill patients with acute pancreatitis: A propensity score-matched study.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDelirium is an acute fluctuating disorder of attention and awareness, which often complicates the clinical course of several conditions, including acute stroke. The aim of the present study was to determine whether delirium occurrence impacts the outcome of patients with acute stroke.
methodsThe study design is single center, prospective, observational. We consecutively enrolled patients admitted to the stroke unit from April to October 2020. Inclusion criteria were age ≥ 18 years and diagnosis of acute stroke. Exclusion criteria were stroke mimics, coma, and terminal conditions. All patients were screened for delirium upon admission, within 72 h, and whenever symptoms suggesting delirium occurred by means of the Confusion Assessment Method for Intensive Care Unit and the Richmond Agitation Sedation Scale. Outcomes were evaluated with the 90-days modified Rankin Scale (mRS) by telephone interview.
resultsThe final study cohort consisted of 103 patients (62 men; median age 75 years, interquartile range 63-81). Thirty-one patients (30%) developed delirium. In the multivariate ordinal logistic regression, patients with delirium had higher mRS scores at 3 months (DLR + : mRS = 4 (3-6); DLR-: mRS = 1 (1-3); adjusted odds ratio = 4.83; CI = 1.88-12.35; p = 0.006). Delirium was a risk factor for death (mRS = 6) in the univariate logistic regression (OR 4.5, CI = 1.44-14.07; p = 0.010), but not in the adjusted analysis (OR 3.45; CI = 0.66-17.95; p = 0.142). Survival time during 90-days follow-up was shorter in the delirium group (Log Rank χ
conclusionDelirium negatively impacts the prognosis of patients with acute stroke. Patients with post-stroke delirium have a worse functional outcome and a shorter survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.