ReviewJournal of endocrinological investigation2023
The role of thyroid function in female and male infertility: a narrative review.
Review in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Meta-Analytical and Meta-Regression Evaluation of Subclinical Hyperthyroidism's Effect on Male Reproductive Health: Hormonal and Seminal Perspectives.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Review
- Article
- Thyroid stimulating hormone (TSH): does it live up to its promises in the andrology laboratory?Basic and clinical andrology · 2026Article
- Review
- [Changes in ovarian function and ovarian reserve after combined treatment for differentiated thyroid cancer].Problemy endokrinologii · 2026Article
- Signal Amplification in the HPT Axis-Evidence for Its Existence, Location, Significance, and Molecular Mechanisms.Acta physiologica (Oxford, England) · 2026Review
- Natural product-based interventions for thyroid disorders: mechanisms and applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Effects of neonatal hypothyroidism on testicular development and undifferentiated spermatogonia in prepubertal rats.Andrology · 2026Article
- Loss of Frmd5 Inhibits Jak2-Stat3 Signalling Pathway and Impairs Cell Apoptosis During Vagina Luminal Formation in Puberty Mice.International journal of biological sciences · 2026Article
- Leveraging electronic health records from two hospital systems identifies male infertility-associated comorbidities across time.Communications medicine · 2025Article
- Research on the Impact of Thyroid Disorders on Reproductive Function: A Narrative Review.Journal of clinical medicine research · 2025Review
- Thyroid and female fertility: a survey on the clinical practice among endocrinologists belonging to the italian thyroid association.Journal of endocrinological investigation · 2025Article
- 50 YEARS OF NEWBORN SCREENING FOR CONGENITAL HYPOTHYROIDISM: EVOLUTION OF INSIGHTS IN ETIOLOGY, DIAGNOSIS AND MANAGEMENT: Management during pregnancy and long-term outcomes of adult patients with congenital hypothyroidism.European thyroid journal · 2025Review
- Causal role of immune cells in male infertility: a Mendelian randomization study.Translational andrology and urology · 2025Article
- Strategies for Signal Amplification of Thyroid Hormones via Electromigration Techniques Coupled with UV Detection and Laser-Induced Fluorescence.International journal of molecular sciences · 2025Article
- Ovarian function measures in normogonadotropic anovulation and subclinical thyroid dysfunction: a prospective cohort study.Endocrine · 2025Article
- Association of thyroid autoimmunity and pregnancy outcomes in unexplained recurrent pregnancy loss women: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review.Frontiers in nutrition · 2025Review
- Altered Expression of Thyroid- and Calcium Ion Channels-Related Genes in Rat Testes by Short-Term Exposure to Commercial Herbicides Paraquat or 2,4-D.Journal of xenobiotics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe herein aimed to review the new insights into the impact of impaired thyroid function on male and female fertility, spacing from spontaneous pregnancy to ART, with the objective of providing an updated narrative revision of the literature.
methodsThis narrative review was performed for all available prospective, retrospective and review articles, published up to 2021 in PubMed. Data were extracted from the text and from the tables of the manuscript.
resultsThyroid dysfunction is frequently associated with female infertility, whereas its link with male infertility is debated. Female wise, impaired function is detrimental to obstetric and fetal outcomes both in spontaneous pregnancies and in those achieved thanks to assisted reproduction technologies (ART). Furthermore, the reference range of TSH in natural pregnancy and ART procedures has recently become a matter of debate following recent reports in this field. On the other hand, the impact of thyroid function on the male reproductive system is less clear, although a possible role is suggested via modulation of Sertoli and Leydig cells function and spermatogenesis.
conclusionThyroid function should be carefully monitored in both male and female, in couples seeking spontaneous pregnancy as well as ART, as treatment is generally immediate and likely to improve chances of success.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.