Evidence map›Paper›PMID 35945369›Full record

ReviewNature reviews. Urology2022

Race and prostate cancer: genomic landscape.

Camilo Arenas-Gallo, Jude Owiredu, Ilon Weinstein, Patrick Lewicki, Spyridon P Basourakos, Randy Vince, Bashir Al Hussein Al Awamlh, Fredrick R Schumacher, Daniel E Spratt, Christopher E Barbieri and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. International journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Disparities With Systemic Therapies for Black Men Having Advanced Prostate Cancer: Where Do We Stand?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  16. Unique Spectrum of Activating BRAF Alterations in Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Camilo Arenas-Gallo *Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-1549-9556
Jude Owiredu *Department of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7361-501X
Ilon WeinsteinDepartment of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Patrick LewickiDepartment of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.
Spyridon P BasourakosDepartment of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7458-4593
Randy VinceDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7779-473X
Bashir Al Hussein Al AwamlhDepartment of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Daniel E SprattDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Christopher E BarbieriDepartment of Urology, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0381-1947
Jonathan E ShoagDepartment of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. jxs218@case.edu.
NewYork–Presbyterian Hospital · USUniversity Hospitals of Cleveland · USCase Western Reserve University · USCornell University · USUniversity Hospitals Seidman Cancer Center · USUniversity of Michigan · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
Pathology CoreU54CA254566 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MADABHUSHI, ANANT · 2020 to 2024
$5.0M
Role of MYC-MIZ1 signaling and the inflammatory immune microenvironment in Triple-Negative Breast Cancer Racial DisparitiesP20CA233216 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI VARADAN, VINAY · 2018 to 2021
$3.6M
Breast Cancer Risk Factors and Epigenetic Age AccelerationR03CA241956 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCHUMACHER, FREDRICK RAY, THOMPSON, CHERYL L · 2020 to 2020
$162k
NCI NIH HHS P20 CA233216NCI NIH HHS P30 CA043703NCI NIH HHS R03 CA241956NCI NIH HHS U54 CA254566
6 · The paper itself

Abstract

In the past 20 years, new insights into the genomic pathogenesis of prostate cancer have been provided. Large-scale integrative genomics approaches enabled researchers to characterize the genetic and epigenetic landscape of prostate cancer and to define different molecular subclasses based on the combination of genetic alterations, gene expression patterns and methylation profiles. Several molecular drivers of prostate cancer have been identified, some of which are different in men of different races. However, the extent to which genomics can explain racial disparities in prostate cancer outcomes is unclear. Future collaborative genomic studies overcoming the underrepresentation of non-white patients and other minority populations are essential.

Indexed as

Prostatic NeoplasmsEpigenomicsGenomicsHumansMaleMutation

Identifiers

PMID35945369
OpenAlexW4294863500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.