SynthesisActa neurochirurgica2022
The need to consider return to work as a main outcome in patients undergoing surgery for diffuse low-grade glioma: a systematic review.
Synthesis in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Risk factors for return to work in workers who experienced cancer: a systematic review with meta-analysis.Oncology reviews · 2026Pooled it
- Symptom burden in young adult brain tumor survivors: Key intervention targets based on patient-reported outcome network analyses.Neuro-oncology practice · 2026Article
- Patient Preferences and Treatment Decision Drivers in IDH-Mutant Grade 2 Glioma: An International Discrete Choice Experiment.The patient · 2026Article
- Evaluating work activity and societal burden in patients with grade 2 IDH-mutant glioma.Neuro-oncology practice · 2026Article
- Neurocognitive functioning, seizure control, and return to work after awake surgery with or without adjuvant therapy in IDH-mutant grade 3 diffuse gliomas.Journal of neuro-oncology · 2026Article
- The neuropsychological outcome of patients undergoing intraoperative MRI surgery for insular infiltrating gliomas.Journal of neuro-oncology · 2026Article
- Multiple Primaries: Differences in Survival of Patients with Glioma with or Without Second Malignancies.Cancers · 2025Article
- Factors associated with cognitive impairment in long-term IDH-mutant glioma survivors.Journal of neuro-oncology · 2025Article
- Barriers and facilitators to self-management in people living with a lower-grade glioma.Journal of cancer survivorship : research and practice · 2025Article
- The deleterious effect of WHO grade II diffuse glioma on socioeconomic status as evaluated through occupation.Scientific reports · 2025Article
- Resection Location and Work Resumption in Patients With Lower-Grade Glioma: A Multicenter Cohort Study.Neurosurgery practice · 2025Article
- Quality and efficiency of a semi-automatic anatomy-based method for tractography of associative white matter fascicles in brain tumor patients, a case series.Neurosurgical review · 2025Article
- Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013-2023).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- Article
- Association between sociodemographic variables and delayed patient presentation among surgical neuro-oncology patients in Mexico City: a single institution experience.Journal of neuro-oncology · 2025Article
- The role of a multidisciplinary clinic for management of patients with IDH mutant gliomas.Frontiers in oncology · 2025Article
- "It changes everything": Understanding how people experience the impact of living with a lower-grade glioma.Neuro-oncology practice · 2024Article
- Verbal fluency predicts work resumption after awake surgery in low-grade glioma patients.Acta neurochirurgica · 2024Article
- High costs, low quality of life, reduced survival, and room for improving treatment: an analysis of burden and unmet needs in glioma.Frontiers in oncology · 2024Review
- Patient and caregiver return to work after a primary brain tumor.Neuro-oncology practice · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFor a long time, return to work (RTW) has been neglected in patients harboring a diffuse low-grade glioma (LGG). However, a majority of LGG patients worked at time of diagnosis. Moreover, these patients now live longer given current treatment paradigms, especially thanks to early maximal surgery.
methodsWe systematically searched available medical databases for studies that reported data on RTW in patients who underwent resection for LGG.
resultsA total of 30 studies were selected: 19 considered RTW (especially rate and timing) as an outcome and 11 used scales of health-related quality of life (HRQoL) which included work-related aspects. Series that considered RTW as a main endpoint were composed of 1014 patients, with postoperative RTW rates ranging from 31 to 97.1% (mean 73.1%). Timing to RTW ranged from 15 days to 22 months (mean 6.3 months). Factors related to an increased proportion of RTW were: younger age, better neurologic status, having a white-collar occupation, working pre-operatively, being the sole breadwinner, the use of awake surgery, and greater extent of resection. Female sex, older age, poor neurologic status, pre-operative history of work absences, slow lexical access speed, and postoperative seizures were negatively related to RTW. No studies that used HRQoL scales directly investigated RTW rate or timing.
conclusionsRTW was scarcely analyzed in LGG patients who underwent resection. However, because they are usually young, with no or only mild functional deficits and have a longer life expectancy, postoperative RTW should be assessed more systematically and accurately as a main outcome. As majority (61.5-100%) of LGG patients were working at time of surgery, the responsibility of neurosurgeons is to bring these patients back to their previous activities according to his/her wishes. RTW might also be included as a critical endpoint for future prospective studies and randomized control trials on LGGs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.