Evidence map›Paper›PMID 35945263›Full record

ArticleInternational journal of obesity (2005)2022

Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts.

Karri Silventoinen, Weilong Li, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Sari Aaltonen, Maarit Piirtola, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto and 47 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Karri SilventoinenPopulation Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland. karri.silventoinen@helsinki.fi.ORCID http://orcid.org/0000-0003-1759-3079
Weilong LiPopulation Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
Aline JelenkovicDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Spain.
Reijo SundInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-6268-8117
Yoshie YokoyamaDepartment of Public Health Nursing, Osaka Metropolitan University, Osaka, Japan.
Sari AaltonenInstitute for Molecular Medicine Finland FIMM, Helsinki, Finland.
Maarit PiirtolaInstitute for Molecular Medicine Finland FIMM, Helsinki, Finland.
Masumi SugawaraFaculty of Human Studies, Shirayuri University, Tokyo, Japan.
Mami TanakaCenter for Forensic Mental Health, Chiba University, Chiba, Japan.
Satoko MatsumotoInstitute for Education and Human Development, Ochanomizu University, Tokyo, Japan.
Laura A BakerDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Catherine TuvbladDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Per TyneliusDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Finn RasmussenDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Jeffrey M CraigThe Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University School of Medicine, Geelong, Australia.
Richard SafferyMurdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-9510-4181
Gonneke WillemsenNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.
Meike BartelsNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-9667-7555
Catharina E M van BeijsterveldtNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.
Nicholas G MartinGenetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sarah E MedlandGenetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3037-5287
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-5580-1433
Shandell PahlenDepartment of Psychology, University of California, Riverside, Riverside, CA, 92521, USA.
Kaare ChristensenThe Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark Odense, Odense, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
Axel SkyttheThe Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark Odense, Odense, Denmark.
Kirsten O KyvikDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Kimberly J SaudinoBoston University, Department of Psychological and Brain Sciencies, Boston, MA, USA.
Lise DuboisSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Michel BoivinÉcole de psychologie, Université Laval, Québec, Canada.
Mara BrendgenDépartement de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada.
Ginette DionneÉcole de psychologie, Université Laval, Québec, Canada.
Frank VitaroÉcole de psychoéducation, Université de Montréal, Montréal, Québec, Canada.
Vilhelmina UllemarDivision of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Brooke M HuibregtseDepartment of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA.ORCID http://orcid.org/0000-0003-0977-7249
Ariel Knafo-NoamThe Hebrew University of Jerusalem, Jerusalem, Israel.
David MankutaHadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel.
Lior AbramsonThe Hebrew University of Jerusalem, Jerusalem, Israel.
Claire M A HaworthSchool of Psychological Science, University of Bristol, Bristol, UK.
Robert PlominSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0756-3629
Morten Bjerregaard-AndersenBandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.
Henning Beck-NielsenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Morten SodemannDepartment of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Glen E DuncanWashington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Dedra BuchwaldWashington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
S Alexandra BurtDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.
Clare H LlewellynDepartment of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, UK.ORCID http://orcid.org/0000-0002-0066-2827
Abigail FisherDepartment of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Thorkild I A SørensenNovo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4821-430X
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455

Funding

Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
The Effects of Estradiol on Genetic Risk for Disordered Eating During PubertyR01MH092377 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2010 to 2014
$3.4M
Integrating contextual, proximal, and individual risks for child conduct problemsR01HD066040 · NICHD · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA · 2010 to 2014
$2.9M
Gene-environment Interactions in Childhood Conduct ProblemsR01MH081813 · NIMH · MICHIGAN STATE UNIVERSITY · PI BURT, S. ALEXANDRA · 2008 to 2013
$1.6M
University of Colorado Interdisciplinary Training in Demography and GeneticsT32AG052371 · NIA · UNIVERSITY OF COLORADO · PI BOARDMAN, JASON D · 2017 to 2020
$681k
Medical Research Council G0901245Medical Research Council MR/M021475/1NIA NIH HHS T32 AG052371NICHD NIH HHS R01 HD066040NIDA NIH HHS T32 DA017637NIMH NIH HHS R01 MH081813NIMH NIH HHS R01 MH092377
6 · The paper itself

Abstract

backgroundBody mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height.

methodsWe pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age.

resultsThe genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood.

conclusionsOur results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity.

Indexed as

Twins, DizygoticTwins, MonozygoticAdolescentAdultBody HeightBody Mass IndexChildChild, PreschoolHumansInfantObesityYoung Adult

Identifiers

PMID35945263
PMCPMC9492534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.