ArticleNature communications2022
Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 72 citations in OpenAlex.
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- Otubain deubiquitinases: Multi-layered regulators of cell fate, development, and stress responses across kingdoms.iScience · 2026Review
- Elemental Profiling of Common Anti-diabetic Medicinal Plants of Swat and Peshawar Districts of Khyber Pakhtunkhwa (KPK) Province of Pakistan: An Investigation Using PIXE and ICP-OES.Biological trace element research · 2025Article
- Finding potential inhibitors from phytochemicals against nucleoprotein of crimean congo fever virus using in silico approach.Scientific reports · 2024Article
- Review
- Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1.Nature communications · 2024Article
- Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism.Molecules (Basel, Switzerland) · 2024Review
- Genome-Wide Association Study for Agronomic Traits in Gamma-Ray-Derived Mutant Kenaf (Plants (Basel, Switzerland) · 2024Article
- Mechanisms of Plant Epigenetic Regulation in Response to Plant Stress: Recent Discoveries and Implications.Plants (Basel, Switzerland) · 2024Review
- Molecular characterization ofPeerJ · 2024Article
- Secretory molecules from secretion systems fine-tune the host-beneficial bacteria (PGPRs) interaction.Frontiers in microbiology · 2024Review
- Genome-Wide Identification and Expression Analysis of Auxin Response Factor (ARF) Gene Family inPlants (Basel, Switzerland) · 2023Article
- Alleviation of chromium toxicity in mung bean (Vigna radiata L.) using salicylic acid and Azospirillum brasilense.BMC plant biology · 2023Article
- Impacts of kinetin implementation on leaves, floral and root-related traits during seed production in hybrid rice under water deficiency.BMC plant biology · 2023Article
- Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes.Nature communications · 2023Article
- Plant deubiquitinases: from structure and activity to biological functions.Plant cell reports · 2023Review
- Emerging Biopharmaceuticals fromMolecules (Basel, Switzerland) · 2023Review
- Plant protection from virus: a review of different approaches.Frontiers in plant science · 2023Review
- The role of plant growth promoting rhizobacteria in strengthening plant resistance to fluoride toxicity: a review.Frontiers in microbiology · 2023Review
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linear (Met1-linked) ubiquitination is involved inflammatory and innate immune signaling. Previous studies have characterized enzymes regulating the addition and removal of this modification in mammalian systems. However, only a few plant-derived deubiquitinases targeting Met1-linked ubiquitin chains have been reported and their mechanism of action remains elusive. Here, using a dehydroalanine-bearing Met1-diubiquitin suicide probe, we discover OTUB1 from Oryza sativa (OsOTUB1) as a Met1-linked ubiquitin chain-targeting deubiquitinase. By solving crystal structures of apo OsOTUB1 and an OsOTUB1/Met1-diubiquitin complex, we find that Met1 activity is conferred by Met1-specific motifs in the S1' pocket of OsOTUB1. Large-scale sequence alignments and hydrolysis experiments provide evidence that these motifs are a general determinant of Met1 activity in the OTUB subfamily across species. Analysis of the species distribution of OTUBs capable of hydrolysing Met1-linked ubiquitin chains shows that this activity is conserved in green plants (Viridiplantae) and does not exist in metazoans, providing insights into the evolutionary differentiation between primitive plants and animals.
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