Evidence map›Paper›PMID 35945221›Full record

ArticleNutrition & diabetes2022

Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics.

Ho Lee, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto and 25 more

Open access · goldAbstract read
In one paragraph

Article in Nutrition & diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 16 institutions in 1 country.

Ho LeeDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Shotaro Chubachi *Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. bachibachi472000@live.jp.ORCID 0000-0002-5046-3762
Ho Namkoong *Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. hounamugun@gmail.com.
Hiromu TanakaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Shiro OtakeDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Kensuke NakagawaraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Atsuho MoritaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Takahiro FukushimaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Mayuko WataseDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Tatsuya KusumotoDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Katsunori MasakiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Hirofumi KamataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.ORCID 0000-0003-4396-1664
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Norihiro HaradaDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0002-0962-5731
Tetsuya UedaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Soichiro UedaJCHO (Japan Community Health Care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Takashi IshiguroDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Ken ArimuraDepartment of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Fukuki SaitoDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Takashi YoshiyamaRespiratory Diseases Center, Fukujuji Hospital, Tokyo, Japan.
Yasushi NakanoDepartment of Internal Medicine, Kawasaki Municipal Ida Hospital, Kawasaki, Japan.
Yoshikazu MutohDepartment of Infectious Diseases, Tosei General Hospital, Seto, Japan.
Yusuke SuzukiDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.ORCID 0000-0001-9357-4852
Koji MurakamiDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Ryuji KoikeMedical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Akinori KimuraInstitute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
Seiya ImotoDivision of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Satoru MiyanoM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Seishi OgawaDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Japan COVID-19 Task Force
Keio University · JPTokyo Medical and Dental University · JPFukujuji Hospital · JPJuntendo University · JPKansai Medical University · JPKawasaki Municipal Hospital · JPKitasato Institute Hospital · JPKyoto University · JPSaiseikai Nakatsu Hospital · JPSaitama Prefecture · JPSocial Insurance Saitama Chuo Hospital · JPThe University of Osaka · JPThe University of Tokyo · JPTohoku University · JPTokyo Women's Medical University · JPTosei General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass index (BMI) in Japan. Thus, this study aimed to investigate the effect of obesity stratified by BMI on the severity of COVID-19 in the general Japanese population.

methodsFrom February 2020 to May 2021, 1 837 patients aged ≥18 years were enrolled in the Japan COVID-19 Task Force. Patients with known BMI and disease severity were analyzed. Severity was defined as critical if the patient was treated in the intensive care unit, required invasive mechanical ventilation, or died.

resultsClass 1 obesity (25.0 ≤ BMI < 30.0 kg/m

conclusionObesity is a risk factor for respiratory failure in Japanese patients with COVID-19, regardless of the degree of obesity. However, it may not cause severe COVID-19 in a dose-response relationship with BMI. COVID-19 patients with mild obesity may benefit from aggressive intensive care.

Indexed as

COVID-19AdolescentAdultBody Mass IndexHumansJapanObesityRetrospective StudiesRisk FactorsSARS-CoV-2

Identifiers

PMID35945221
PMCPMC9360639
OpenAlexW4290737486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.