Evidence map›Paper›PMID 35945023›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Progressive Multifocal Leukoencephalopathy in a Patient with Multifocal Neurological Manifestations Caused by Solitary Brainstem Involvement.

Akito Funatsu, Kazuo Nakamichi, Midori Araki, Tetsuya Fukumoto, Hideki Mine

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Akito FunatsuCenter for Clinical Education and Training, Takamatsu Red Cross Hospital, Japan.
Kazuo NakamichiDepartment of Virology 1, National Institute of Infectious Diseases, Japan.
Midori ArakiDepartment of Neurology, Takamatsu Red Cross Hospital, Japan.
Tetsuya FukumotoDepartment of Hematology, Takamatsu Red Cross Hospital, Japan.
Hideki MineDepartment of Neurology, Takamatsu Red Cross Hospital, Japan.
Takamatsu Red Cross Hospital · JPNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A Japanese man in his 60s on medication for chronic lymphocytic leukemia presented with progressive, multifocal neurological manifestations. Magnetic resonance imaging showed a small, solitary region of brainstem involvement. Sensitive real-time polymerase chain reaction testing detected a small amount of JC virus (JCV) DNA (170 copies/mL) with pathogenic mutation in cerebrospinal fluid. We diagnosed the patient with progressive multifocal leukoencephalopathy (PML). The small PML lesion may have caused multifocal neurological symptoms because of its focal brainstem involvement. This case contributes to knowledge regarding the diagnosis and treatment of brainstem PML in the context of hematologic malignancies and other underlying diseases.

Indexed as

JC VirusLeukemia, Lymphocytic, Chronic, B-CellLeukoencephalopathy, Progressive MultifocalBrain StemDNA, ViralHumansMaleDNA, ViralbrainstemJC viruslesion volumeprogressive multifocal leukoencephalopathyreal-time polymerase chain reactionsolitary lesion

Identifiers

PMID35945023
PMCPMC10036997
OpenAlexW4291632956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.