Evidence map›Paper›PMID 35944998›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Shared and Distinct Functional Effects of Patient-Specific

Marissa Co, Rebecca A Barnard, Jennifer N Jahncke, Sally Grindstaff, Lev M Fedorov, Andrew C Adey, Kevin M Wright, Brian J O'Roak

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Detailed phenotyping of Tbr1-2A-CreER knock-in mice demonstrates significant impacts on TBR1 protein levels and axon development.Autism research : official journal of the International Society for Autism Research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marissa CoDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0000-0002-6764-0171
Rebecca A BarnardDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239.
Jennifer N JahnckeVollum Institute, Oregon Health & Science University, Portland, Oregon 97239.
Sally GrindstaffDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239.
Lev M FedorovTransgenic Mouse Models Core, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0000-0002-1886-4566
Andrew C AdeyDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239.
Kevin M WrightVollum Institute, Oregon Health & Science University, Portland, Oregon 97239.ORCID https://orcid.org/0000-0001-5094-5270
Brian J O'RoakDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97239 oroak@ohsu.edu.ORCID https://orcid.org/0000-0002-4141-0095
Oregon Health & Science University · US

Funding

Characterizing patient-specific TBR1 mutations: Understanding a master regulator of autism risk.R01MH113926 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Brian James O'Roak · 2017 to 2026
$3.5M
NIMH NIH HHS R01 MH113926
6 · The paper itself

Abstract

T-Box Brain Transcription Factor 1 (TBR1) plays essential roles in brain development, mediating neuronal migration, fate specification, and axon tract formation. While heterozygous loss-of-function and missense

Indexed as

DNA-Binding ProteinsNeurogenesisT-Box Domain ProteinsAnimalsAxonsFemaleHumansMaleMiceMice, KnockoutMutationDNA-Binding ProteinsT-Box Domain ProteinsTBR1 protein, humanTbr1 protein, mouseautismcortexdevelopmental biologygeneticsmouseTBR1

Identifiers

PMID35944998
PMCPMC9480892
OpenAlexW4290779878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.