ArticleJournal of the mechanical behavior of biomedical materials2022
Ex vivo experimental characterizations for understanding the interrelationship between tissue mechanics and collagen microstructure of porcine mitral valve leaflets.
Article in Journal of the mechanical behavior of biomedical materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pyriphenone modification of glutaraldehyde pretreated bovine pericardium mitigates advanced glycation end products, calcification, and platelet adhesion.Acta biomaterialia · 2026Article
- Transcatheter measurement of mitral valve coaptation pressure: A proof-of-concept study using animal models.Bioengineering & translational medicine · 2026Article
- Full-Field Assessment of Geometry and Collagenous Architecture of Porcine Valve Leaflets via Laser Micrometry and Quantitative Polarized Light Imaging.Journal of biophotonics · 2025Article
- HETEROGENEOUS PERIDYNAMIC NEURAL OPERATORS: DISCOVER BIOTISSUE CONSTITUTIVE LAW AND MICROSTRUCTURE FROM DIGITAL IMAGE CORRELATION MEASUREMENTS.Foundations of data science (Springfield, Mo.) · 2025Article
- FEBio FINESSE: An Open-Source Finite Element Simulation Approach to Estimate In Vivo Heart Valve Strains Using Shape Enforcement.Annals of biomedical engineering · 2025Article
- Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications.Scientific reports · 2024Article
- The effects of leaflet material properties on the simulated function of regurgitant mitral valves.Journal of the mechanical behavior of biomedical materials · 2023Article
- The Effects of leaflet material properties on the simulated function of regurgitant mitral valves.ArXiv · 2023Article
- Benchtop characterization of the tricuspid valve leaflet pre-strains.Acta biomaterialia · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Unidirectional blood flow in the left side of the heart is regulated by the mitral valve. To better understand the mitral valve function, researchers have examined the structural and mechanical properties of the mitral valve leaflets; however, limitations of the previous studies include the use of mechanics- and structure-altering tissue modifications (e.g., optical clearing) that limit the ability to quantify the unique load-dependent reorientation and realignment of the collagen fibers as well as their interrelation with the valve tissue mechanics. Herein, we aimed to circumvent these limitations by utilizing an integrated polarized-light imaging and biaxial testing system for understanding the mechanics-microstructure interrelationship for porcine mitral valve leaflets. We further performed constitutive modeling and evaluated the accuracy of the affine fiber kinematics theory. From the tissue mechanics perspective, the posterior leaflet was more extensible in the radial direction than the anterior leaflet (14.2% difference in radial tissue stretch), while exhibiting smaller collagen and elastin moduli based on the determined constitutive model parameters. From the collagen microstructure's standpoint, the posterior leaflet had smaller increases in optical anisotropy (closely related to the degree of fiber alignment) than the anterior leaflet (32.8±7.7% vs. 50.0±19.7%). Further, the leaflets were found to possess two distinct fiber families - one family oriented along the circumferential tissue direction, and another more disperse family with a 30°-40° offset from the first fiber family. Finally, affine fiber kinematics consistently underpredicted the collagen fiber reorientations Overall, this study improved our understanding of the mitral valve leaflets that is essential for facilitating tissue-emulated valve replacement and cardiac valve modeling frameworks.
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