Evidence map›Paper›PMID 35943986›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter.

Maxim Katsenelson, Ilana Shapira, Eman Abbas, Kristina Jevdokimenko, Boaz Styr, Antonella Ruggiero, Saba Aïd, Eugenio F Fornasiero, Martin Holzenberger, Silvio O Rizzoli and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Maxim KatsenelsonDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel.ORCID 0000-0001-5561-7065
Ilana ShapiraDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel.
Eman AbbasDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.
Kristina JevdokimenkoDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.
Boaz StyrDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel.
Antonella RuggieroDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel.ORCID 0000-0002-0137-0092
Saba AïdINSERM and Sorbonne University, Research Center UMR 938, 75012 Paris, France.ORCID 0000-0002-1427-581X
Eugenio F FornasieroDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.ORCID 0000-0001-7643-4962
Martin HolzenbergerINSERM and Sorbonne University, Research Center UMR 938, 75012 Paris, France.
Silvio O RizzoliDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.ORCID 0000-0002-1667-7839
Inna SlutskyDepartment of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel.ORCID 0000-0002-0700-2266
Tel Aviv University · ILUniversitätsmedizin Göttingen · DEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of firing rate homeostasis constitutes a fundamental property of central neural circuits. While intracellular Ca

Indexed as

CalciumCalcium ChannelsReceptor, IGF Type 1AnimalsGene DeletionHomeostasisMiceNeuronal PlasticityReproducibility of ResultsCalciumCalcium Channelsmitochondrial calcium uniporterReceptor, IGF Type 1firing rate homeostasishomeostatic plasticityIGF-1 receptorMCUmitochonria

Identifiers

PMID35943986
PMCPMC9388073
OpenAlexW4291019204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.