ArticleAnnals of biomedical engineering2022
Aortic Dissection is Determined by Specific Shape and Hemodynamic Interactions.
Article in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Literature review analysis of aortitis induced by granulocyte-colony stimulating factor.Frontiers in pharmacology · 2024Pooled it
- Predicting Hypertension Persistence in Coarctation of the Aorta: A Feasibility Study.Annals of biomedical engineering · 2026Article
- Linking shape and clinical outcomes: Statistical shape model of Bidirectional Glenn connection in congenital single ventricle patients.PLOS digital health · 2026Article
- Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection.Biomechanics and modeling in mechanobiology · 2025Article
- Article
- Reduced order computational fluid dynamic simulations in the thoracic aorta are associated with disease recorded in a medical biobank.Scientific reports · 2025Article
- Retearing of type B blind cystic aortic dissection: computational fluid dynamics analysis.Physical and engineering sciences in medicine · 2025Article
- Progression from Initial Lesions to Type B Aortic Dissection: A Patient-Specific Study of Computational Fluid Dynamics Models with Follow-up Data.Current medical science · 2025Article
- Computational fluid dynamics modelling of hemodynamics in aortic aneurysm and dissection: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Probing the limits and capabilities of diffusion models for the anatomic editing of digital twins.NPJ digital medicine · 2024Article
- Effect of upper body venoarterial ECMO on systemic hemodynamics and oxygenation: A computational study.Computers in biology and medicine · 2024Article
- Aortic shape with high-acute isthmic angle post frozen elephant trunk reconstruction is associated with worse postoperative outcomes: Multisite, principal component analysis, retrospective study.JTCVS structural and endovascular · 2024Article
- Type B aortic dissection in Marfan patients after the David procedure: Insights from patient-specific simulation.JTCVS open · 2024Article
- The role of anatomic shape features in the prognosis of uncomplicated type B aortic dissection initially treated with optimal medical therapy.Computers in biology and medicine · 2024Article
- The correlation study between the length and angle of ascending aortic and the incidence risk of acute type A aortic dissection.Frontiers in cardiovascular medicine · 2024Article
- The Influence of Minor Aortic Branches in Patient-Specific Flow Simulations of Type-B Aortic Dissection.Annals of biomedical engineering · 2023Article
- Aortic shape variation after frozen elephant trunk procedure predicts aortic events: Principal component analysis study.JTCVS open · 2023Article
- Wall shear stress: the challenges of a rising imaging marker in current clinical practice.Journal of thoracic disease · 2023Article
- Recent developments in modeling, imaging, and monitoring of cardiovascular diseases using machine learning.Biophysical reviews · 2023Review
- Predicting one-year left ventricular mass index regression following transcatheter aortic valve replacement in patients with severe aortic stenosis: A new era is coming.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
The aim of this study was to determine whether specific three-dimensional aortic shape features, extracted via statistical shape analysis (SSA), correlate with the development of thoracic ascending aortic dissection (TAAD) risk and associated aortic hemodynamics. Thirty-one patients followed prospectively with ascending thoracic aortic aneurysm (ATAA), who either did (12 patients) or did not (19 patients) develop TAAD, were included in the study, with aortic arch geometries extracted from computed tomographic angiography (CTA) imaging. Arch geometries were analyzed with SSA, and unsupervised and supervised (linked to dissection outcome) shape features were extracted with principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), respectively. We determined PLS-DA to be effective at separating dissection and no-dissection patients ([Formula: see text]), with decreased tortuosity and more equal ascending and descending aortic diameters associated with higher dissection risk. In contrast, neither PCA nor traditional morphometric parameters (maximum diameter, tortuosity, or arch volume) were effective at separating dissection and no-dissection patients. The arch shapes associated with higher dissection probability were supported with hemodynamic insight. Computational fluid dynamics (CFD) simulations revealed a correlation between the PLS-DA shape features and wall shear stress (WSS), with higher maximum WSS in the ascending aorta associated with increased risk of dissection occurrence. Our work highlights the potential importance of incorporating higher dimensional geometric assessment of aortic arch anatomy in TAAD risk assessment, and in considering the interdependent influences of arch shape and hemodynamics as mechanistic contributors to TAAD occurrence.
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