Evidence map›Paper›PMID 35943575›Full record

Observational studyPediatric nephrology (Berlin, Germany)2023

Long-term complications in patients with childhood-onset nephrotic syndrome.

Joyita Bharati, Karalanglin Tiewsoh, Lesa Dawman, Tarvinder Singh, Ujjwal Gorsi, Arun Prabhahar Rajarajen, Aakanksha Sharma, Rahul Chanchlani, Raja Ramachandran, Harbir Singh Kohli

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Challenging Clinical Practice Guideline Definitions in Childhood Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Joyita BharatiDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Karalanglin TiewsohDepartment of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Lesa DawmanDepartment of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Tarvinder SinghDepartment of Radiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ujjwal GorsiDepartment of Radiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Arun Prabhahar RajarajenDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Aakanksha SharmaDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Rahul ChanchlaniDivision of Nephrology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, ON, Canada.
Raja RamachandranDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Harbir Singh KohliDepartment of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. kohlihs2009@gmail.com.
Post Graduate Institute of Medical Education and Research · INMcMaster Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReports on long-term complications of childhood-onset nephrotic syndrome (NS), such as obesity, osteoporosis, growth failure, and hypertension, are mostly from developed countries not representing South Asian ethnicities. Furthermore, data on cardiovascular health among patients with childhood-onset NS are limited.

methodsThis was an observational study involving patients attending a tertiary care center. Patients aged 15 years and older were examined for long-term complications and remission of NS at their visit in December 2021. Childhood-onset NS meant onset of NS before 10 years of age. Long-term complications included obesity, growth failure, low bone mineral density (BMD) Z score, hypertension, and increased carotid intima-media thickness (cIMT). Long-term remission was defined as no relapse for the last [Formula: see text] 3 consecutive years without immunosuppressive medication to maintain remission.

resultsOf 101 patients studied (~ 80% with frequent relapsing (FR)/steroid-dependent (SD) NS), the mean age was 17.6 (± 2.4) years at the time of study. Long-term complications were noted in 89.1% of patients which included one or more of the following: obesity (22.7%), growth failure (31.7%), low BMD Z score (53.5%), hypertension (31.7%), and high cIMT (50.5%). Thirty-nine patients (38.6%) were in long-term remission at the time of the study. Growth failure and low BMD Z scores were less frequent in patients with long-term remission compared to those without long-term remission.

conclusionsIn patients with childhood-onset NS (predominantly FR/SDNS) who were studied at [Formula: see text] 15 years of age, ~ 90% had long-term complications which included high cIMT in 50%. Only ~ 40% were in long-term remission. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

HypertensionNephrotic SyndromeAdolescentCarotid Intima-Media ThicknessChildHumansImmunosuppressive AgentsObesityRecurrenceImmunosuppressive AgentsChildhood-onsetcIMTIndian patientsLong-term complicationsNephrotic syndrome

Identifiers

PMID35943575
OpenAlexW4290771877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.