SynthesisArchives of gynecology and obstetrics2023
The optimal route of progesterone administration for luteal phase support in a frozen embryo transfer: a systematic review.
Synthesis in Archives of gynecology and obstetrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Trial
- Comparing the outcomes of in-vitro fertilization in patients receiving vaginal, subcutaneous, and intramuscular progesterone for luteal phase support: a three-armed randomized controlled trial.BMC women's health · 2024Trial
- Progesterone Levels on the Day of Frozen-thawed Embryo Transfer in Artificial Cycles with Vaginal Progesterone Do not Predict Clinical Pregnancy: a Prospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- The relationship between serum estradiol and progesterone levels one day before frozen embryo transfer and pregnancy rates in artificially prepared frozen embryo cycles: are there any threshold serum hormone levels to predict pregnancy in luteal support by the vaginal and subcutaneous route combined?Journal of the Turkish German Gynecological Association · 2025Article
- Oral Dydrogesterone Versus Vaginal Progesterone for Luteal Phase Support in Frozen-Thawed Embryo Transfer Cycles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2025Review
- The Effect of Adding Daily 50 mg Intramuscular Progesterone to 800 mg Progesterone Suppository on TheInternational journal of fertility & sterility · 2024Article
- Current Ovulation and Luteal Phase Tracking Methods and Technologies for Fertility and Family Planning: A Review.Seminars in reproductive medicine · 2024Review
- No additional risk of congenital anomalies after first-trimester dydrogesterone use: a systematic review and meta-analysis.Human reproduction open · 2024Review
- Association between serum progesterone levels on the day of frozen-thawed embryo transfer and pregnancy outcomes after artificial endometrial preparation.BMC pregnancy and childbirth · 2023Article
- Combined Progesterone Administration Versus Single-Route Administration for Luteal Phase Support in IVF: A Narrative Review of Current Evidence.Journal of reproduction & infertilityReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the optimal route of progesterone administration for luteal phase support in a frozen embryo transfer.
designSystematic review. PATIENTS: Women undergoing frozen embryo transfer (FET).
interventionsWe conducted an extensive database search of Medline (PubMed), Embase, Web of Science, and Cochrane Trials Register using relevant keywords and their combinations to find randomized controlled trials (RCTs) comparing the routes (i.e., oral, vaginal, intramuscular) of progesterone administration for luteal phase support (LPS) in artificial FET.
main outcome measuresClinical pregnancy, live birth, miscarriage.
resultsFour RCTs with 3245 participants undergoing artificial endometrial preparation (EP) cycles during FET were found to be eligible. Four trials compared vaginal progesterone with intramuscular progesterone and two trials compared vaginal progesterone with oral progesterone. One study favored of vaginal versus oral progesterone for clinical pregnancy rates (RR 0.45, 95% CI 0.22-0.92) and other study favored intramuscular versus vaginal progesterone for clinical pregnancy rates (RR 1.46, 95% CI 1.21-1.76) and live birth rates (RR 1.62, 95% CI 1.28-2.05). Tabulation of overall evidence strength assessment showed low-quality evidence on the basis that for each outcome-comparison pair, there were deficiencies in either directness of outcome measurement or study quality.
conclusionThere was little consensus and evidence was heterogeneous on the optimal route of administration of progesterone for LPS during FET in artificial EP cycles. This warrants more trials, indirect comparisons, and network meta-analyses. PROPERO NO: CRD42021251017.
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