ReviewJournal of oral & facial pain and headache
Psychologic Impact of Chronic Orofacial Pain: A Critical Review.
Review in Journal of oral & facial pain and headache. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Efficacy of duloxetine in treating temporomandibular joint disorder: a systematic review with bayesian meta-analysis.BMC oral health · 2025Pooled it
- Dry needling, lidocaine, and mepivacaine for myofascial pain and associated temporomandibular disorder and depressive symptoms: a randomized clinical trial.BMC oral health · 2026Trial
- Oral health and mental health: lived experiences of stigma and discrimination for Australians with mental health conditions.BMC oral health · 2026Article
- Characterizing pain and psychosocial profiles in adolescents with temporomandibular disorders: A cross-sectional case-control study.Journal of the American Dental Association (1939) · 2026Article
- Prevalence of Emotional Factors and Pain in Temporomandibular Disorder and Correlation With Different Diagnoses: A Cross-Sectional Study.Journal of oral rehabilitation · 2026Observational
- Oral Health-Related Quality of Life and Self-Reported Oral Health Status Are Associated with Change in Self-Reported Depression Status: A Cohort Study.Journal of clinical medicine · 2026Article
- Orofacial Pain at a Tertiary Clinic: Comorbidities and Psychological Conditions Using the International Classification of Orofacial Pain (ICOP) Criteria.Journal of pain research · 2026Article
- Dental drugs with proarrhythmic risk in patients with Brugada syndrome: precaution instructions for practices in the field of orofacial pain.Frontiers in cardiovascular medicine · 2026Review
- Decoding orofacial pain: a translational review of mechanisms and novel therapies.The journal of headache and pain · 2025Review
- Assessment of Common Oral Behaviors in Patients with Temporomandibular Joint Disorders and Their Relationship to Psychosocial Factors.Dentistry journal · 2025Article
- Sex differences of synaptic plasticity and microglial remodeling in the dorsal hippocampus following trigeminal nerve injury in mice.Neurobiology of disease · 2025Article
- Substance Use Among Adults with Chronic Orofacial Pain.Journal of clinical psychology in medical settings · 2025Article
- Associations between pain, anxiety and depression and mindfulness in patients with burning mouth syndrome: a cross-sectional study.Journal of oral & facial pain and headache · 2025Article
- Chain mediation of anxiety and suicidal ideation: a 2021-2025 cross-sectional analysis in Chinese temporomandibular disorders patients.BMC psychiatry · 2025Article
- Genetic prediction of blood metabolites and causal relationships with pain associated with temporomandibular disorders: a Mendelian randomization study.Journal of oral & facial pain and headache · 2025Article
- Symptomatic irreversible pulpitis and other orofacial pain: overcoming challenges in diagnosis and management.British dental journal · 2025Review
- Suicidal Ideation and Self-Injury in Trigeminal Neuralgia.Journal of pain research · 2025Article
- Article
- Oral pain and comorbidities in an edentulous older population: A k-prototypes cluster analysis.PloS one · 2025Article
- The potential association between sedentary behaviors and risk of temporomandibular disorders: evidence from Mendelian randomization analysis.Journal of oral & facial pain and headache · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo explore the prevalence of clinically significant anxiety and depression in adult patients with chronic orofacial pain (COFP) conditions.
methodsA systematic online search of the Medline (PubMed) and Ovid databases was performed for articles published from 2006 to 2019. Observational studies- including cross-sectional, case-control, and case series-and longitudinal prospective studies were included. A total of 118 articles were selected for inclusion, and the prevalence rates of clinically significant anxiety and depression were summarized.
resultsMost studies focused on temporomandibular disorder (TMD) pain and less often on neuropathic COFP conditions. Prevalence rates varied widely across studies according to OFP condition and assessment measure; most questionnaire-based assessments yielded rates of clinically significant depression and anxiety in, respectively, 40% to 60% and 40% to 65% of individuals with TMD and in 20% to 50% and 25% to 55% of patients with neuropathic, mixed, or idiopathic/atypical COFP conditions. Rates of anxiety and depression were lower in studies using diagnostic instruments and in TMD studies with nonpatient samples. Most controlled studies showed a higher prevalence of anxiety and depression in individuals with COFP than in those without. Higher COFP pain levels and the presence of comorbid conditions such as migraines or widespread pain increased the likelihood of anxiety and/or depressive symptoms in individuals.
conclusionClinically significant anxiety and depression were commonly observed in patients with COFP, were present at higher rates than in pain-free participants in controlled studies, and were closely linked to pain severity. More research is needed to evaluate the psychologic impact of multiple COFP conditions in an individual and the prevalence of precondition psychologic morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.