ArticlemSphere2022
Interrelated Effects of Zinc Deficiency and the Microbiome on Group B Streptococcal Vaginal Colonization.
Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- Type 2 diabetes mellitus exacerbates vaginal group BmSphere · 2026Article
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- Microbe on the move:Journal of bacteriology · 2026Review
- Type 2 diabetes mellitus exacerbates vaginal group BbioRxiv : the preprint server for biology · 2026Article
- Exploring the vaginal ecosystem: insights into host-microbe interactions and microbial community dynamics.Infection and immunity · 2025Review
- Vaginal microbiota alterations under supraphysiological estradiol state during in vitro fertilization-embryo transfer (IVF-ET) and the association with reproductive outcomes.BMC microbiology · 2025Article
- Influence of cervicovaginal microbiota onMicrobial cell (Graz, Austria) · 2025Review
- Adaptation to zinc restriction inmSphere · 2024Article
- Re-framing the importance of Group BInfection and immunity · 2024Review
- Diet influences community dynamics following vaginal group B streptococcus colonization.Microbiology spectrum · 2024Article
- Article
- Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model.NPJ biofilms and microbiomes · 2023Article
- Interspecies Interactions within the Host: the Social Network of Group BInfection and immunity · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Group B Streptococcus (GBS) in the vaginal tract is a risk factor for preterm birth and adverse pregnancy outcomes. GBS colonization is also transient in nature, which likely reflects the contributions of pathogen determinants, interactions with commensal flora, and host factors, making this environment particularly challenging to understand. Additionally, dietary zinc deficiency is a health concern on the global scale that is known to be associated with recurrent bacterial infection and increased rate of preterm birth or stillbirth. However, the impact of zinc deficiency on vaginal health has not yet been studied. Here we use a murine model to assess the role of dietary zinc on GBS burden and the impact of GBS colonization on the vaginal microbiome. We show that GBS vaginal colonization is increased in a zinc-deficient host and that the presence of GBS significantly alters the microbial community structure of the vagina. Using machine learning approaches, we show that vaginal community turnover during GBS colonization is driven by computationally predictable changes in key taxa, including several organisms not previously described in the context of the vaginal microbiota, such as Akkermansia muciniphila. We observed that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.