Evidence map›Paper›PMID 35943160›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.

Elizabeth O Harrington, Ashok Kumar, Verida Leandre, Zachary S Wilson, Brianna Guarino, Julie Braza, Craig T Lefort, James R Klinger

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Deletion of thePulmonary circulation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elizabeth O HarringtonVascular Research Lab, Providence Veterans Administration Medical Center, Providence, Rhode Island.ORCID 0000-0002-3207-5301
Ashok KumarVascular Research Lab, Providence Veterans Administration Medical Center, Providence, Rhode Island.
Verida LeandrePathobiology Graduate Program, Brown University, Providence, Rhode Island.ORCID 0000-0001-7494-1055
Zachary S WilsonPathobiology Graduate Program, Brown University, Providence, Rhode Island.
Brianna GuarinoVascular Research Lab, Providence Veterans Administration Medical Center, Providence, Rhode Island.
Julie BrazaVascular Research Lab, Providence Veterans Administration Medical Center, Providence, Rhode Island.
Craig T LefortDivision of Surgical Research, Department of Surgery, Rhode Island Hospital, Providence, Rhode Island.
James R KlingerVascular Research Lab, Providence Veterans Administration Medical Center, Providence, Rhode Island.ORCID 0000-0003-2997-5955
Brown University · USProvidence VA Medical Center · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Selective Modulation of Neutrophils in Critical IllnessR35GM124911 · NIGMS · RHODE ISLAND HOSPITAL · PI CRAIG THOMAS LEFORT · 2017 to 2026
$3.8M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
The Role of NPR-C In Modulation Of Acute Lung InjuryR01HL123965 · NHLBI · RHODE ISLAND HOSPITAL · PI HARRINGTON, ELIZABETH O, KLINGER, JAMES RAYMOND · 2015 to 2018
$1.2M
A murine model of Pseudomonas aeruginosa pneumonia secondary to hemorrhagic shockR03AI130526 · NIAID · RHODE ISLAND HOSPITAL · PI LEFORT, CRAIG THOMAS · 2017 to 2018
$161k
NHLBI NIH HHS R01 HL123965NHLBI NIH HHS R25 HL088992NHLBI NIH HHS T32 HL134625NIAID NIH HHS R03 AI130526NIGMS NIH HHS P20 GM103652NIGMS NIH HHS R35 GM124911
6 · The paper itself

Abstract

Atrial natriuretic peptide (ANP) protects against acute lung injury (ALI), but the receptor that mediates this effect is not known. Transgenic mice with 0 (knockout), 1 (heterozygote), or 2 (wild-type) functional copies of

Indexed as

Acute Lung InjuryAtrial Natriuretic FactorAnimalsCytokinesLungMiceMice, KnockoutMice, TransgenicNeutrophil InfiltrationReceptors, Atrial Natriuretic FactorAtrial Natriuretic Factoratrial natriuretic factor receptor CCytokinesReceptors, Atrial Natriuretic Factoracute lung injuryatrial natriuretic peptidecytokineslung inflammationnatriuretic peptide receptor C

Identifiers

PMID35943160
PMCPMC9529260
OpenAlexW4297458465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.