Evidence map›Paper›PMID 35943017›Full record

ArticleArchives of Iranian medicine2022

Risk of Bias in Iranian Randomized Trials Included in Cochrane Reviews.

Ali Kabir, Ahmad Sofi-Mahmudi, Arman Karimi Behnagh, Vahid Eidkhani, Hamid Reza Baradaran, Payam Kabiri, AliAkbar Haghdoost, Bita Mesgarpour

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In one paragraph

Article in Archives of Iranian medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ali KabirMinimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-9496-4705
Ahmad Sofi-MahmudiCochrane Iran Associate Centre, National Institute for Medical Research Development (NIMAD), Tehran, Iran.ORCID 0000-0001-6829-0823
Arman Karimi BehnaghMinimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-6391-2371
Vahid EidkhaniMinimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-0705-5111
Hamid Reza BaradaranEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-5070-5864
Payam KabiriDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-7634-370X
AliAkbar HaghdoostSocial Determinants of Health Research Centre, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.ORCID 0000-0003-4628-4849
Bita MesgarpourCochrane Iran Associate Centre, National Institute for Medical Research Development (NIMAD), Tehran, Iran.ORCID 0000-0002-4004-8493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong interventional studies, randomized controlled trials (RCTs) provide the highest level of evidence. However, RCTs can be susceptible to the risk of bias (RoB). Systematic reviews can be performed to appraise RoB in the included articles using evaluative tools. This study aimed to describe the main characteristics and focus on the RoB of RCTs conducted in Iran and included in Cochrane Reviews (CRs).

methodsWe searched "Iran" by selecting the "Search All Text" and "Review" fields in the

resultsOut of 1166 Iranian RCTs included by 571 CRs, low RoB was found in 44.9% for random sequence generation, 20.8% for allocation concealment, 32.3% for blinding of participants/personnel, 36.5% for blinding of outcome assessors, 56.3% for incomplete outcome data, 41.3% for selective outcome reporting and 53.8% for other sources of bias.

conclusionThe RoB in Iranian RCTs was found to be mostly high or unclear. While this is similar to the global situation, it is recommended that the methodological quality of conducting and reporting RCTs be addressed in Iran.

Indexed as

Research DesignBiasHumansIranRandomized Controlled Trials as TopicSystematic Reviews as TopicCochraneEvidence-based medicineIranRandomized controlled trialSystematic review

Identifiers

PMID35943017
PMCPMC11904274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.