ArticleCancer reports (Hoboken, N.J.)2023
Rhabdomyosarcoma in children: Retrospective analysis from a single tertiary care center in Saudi Arabia.
Article in Cancer reports (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Non-metastatic pediatric head and neck rhabdomyosarcoma: a 24-year retrospective experience from Jordan.Frontiers in pediatrics · 2026Article
- Prognostic factors in pediatric head and neck rhabdomyosarcoma: a 30-year retrospective study in Brazil.Brazilian oral research · 2026Article
- Evaluation of clinical and imaging features for differentiating rhabdomyosarcoma from neuroblastoma in pediatric soft tissue.Frontiers in oncology · 2024Article
- Rhabdomyosarcoma in children: Retrospective analysis from a single tertiary care center in Saudi Arabia.Cancer reports (Hoboken, N.J.) · 2023Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundRhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children occurring most commonly in the head and neck region. The treatment involves using a multimodality approach including chemotherapy, surgery, and radiation therapy. Survival for patients with localized disease has improved markedly, but the treatment of advanced disease remains a challenge. We report the clinical characteristics and outcome for patients treated at a tertiary care center in Saudi Arabia.
methodsPatients aged 0-14 years diagnosed with RMS between 2005 and 2018 were included. Statistical analysis was performed using SPSS software. Kaplan-Meier method was used to calculate overall and event free survival. Cox proportional hazards model was used for multivariate analysis.
resultsOne hundred and twenty-four patients were analyzed. The median age was 5.7 years with male predominance (2.4:1). The most common primary sites were head/neck (30%) and the genitourinary tract (25%). Embryonal RMS was present in 81%; alveolar in 19%. Most patients had intermediate risk disease (60%). The 5-year overall and event free survivals were 64.3% and 53.3%, respectively. Survival was influenced by primary tumor site, histology, and clinical risk group. Unfavorable primary site, high risk stratification, and poor initial response to therapy predicted a poor outcome.
conclusionThis study provides an insight on the current management outcomes for our patients with RMS. Cytogenetics and molecular diagnostics need to be incorporated as standard of care in the therapeutic approach of our patients. In addition, there is a need for national collaborative efforts to improve the outcome of RMS in children and adolescents.
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