ReviewXenotransplantation2022
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?
Review in Xenotransplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Optimizing IVIg in Xenotransplantation: A Call to Action.Transplantation · 2026Article
- Considering the Risks and Costs of Solid Organ Xenotransplantation.Advanced biology · 2025Article
- Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea.Diabetes & metabolism journal · 2024Article
- Clinical Pig Heart Xenotransplantation-Where Do We Go From Here?Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection.Xenotransplantation · 2023Article
- Milestones on the path to clinical pig organ xenotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Review
- Xenotransplantation: A historical-ethical account of viewpoints.Xenotransplantation · 2023Review
- Cardiac xenotransplantation: from concept to clinic.Cardiovascular research · 2023Review
- The history of cardiac xenotransplantation: early attempts, major advances, and current progress.Frontiers in transplantation · 2023Review
- Bioethics and xenotransplantation from pig to human.Clinics (Sao Paulo, Brazil) · 2023Article
- Zwitterionic coating assisted by dopamine with metal-phenolic networks loaded on titanium with improved biocompatibility and antibacterial property for artificial heart.Frontiers in bioengineering and biotechnology · 2023Article
- How, where and when to screen for porcine cytomegalovirus (PCMV) in donor pigs for xenotransplantation.Scientific reports · 2022Article
- Treatment of Presumptive Rejection After Orthotopic Pig-to-Baboon Cardiac Xenotransplantation.XenotransplantationArticle
- Detection of Anti-Non-α-Gal Xenoreactive Antibodies in Human Blood Products.XenotransplantationArticle
- Sex Differences in Maturation and Function of Neonatal Porcine Islets Upon Transplantation in Mice.XenotransplantationArticle
- An Immunological and Translational Framework for Interspecies Exogenic Liver Transplantation.Cell transplantationReview
- Antibody-mediated rejection in xenotransplantation: Can it be prevented or reversed?XenotransplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The clinical course of the first patient to receive a gene-edited pig heart transplant was recently reported by the University of Maryland team. Although the pig heart functioned well for >40 days, serum anti-pig antibodies then increased, and the patient sadly died after 60 days. Because of his debilitated pre-transplant state, the patient never thrived despite excellent graft function for several weeks, and the cause of his demise continues to be uncertain. A few days before an increase in anti-pig antibodies was observed, the patient had received intravenous human immunoglobulin (IVIg), and whether this played a role in his cardiac deterioration has been discussed. Furthermore, mcfDNA testing indicated an increase in pig cytomegalovirus (CMV), and its possible role in the development of cardiac dysfunction has also been considered. On the basis of the limited data provided in the publication and on our previous investigations into whether IVIg contains anti-TKO pig antibodies and therefore might be deleterious to TKO pig organ xenografts, we suggest that the steady rise in anti-pig antibody titer was more consistent with the failure of the immunosuppressive regimen to prevent elicited anti-TKO pig antibody production, rather than from the passive transfusion of IVIg or the presence of pig CMV in the graft. Although the outcome of the Maryland experience was disappointing, valuable lessons were learned. Our attention was drawn to the potential risks of heart transplantation in a "deconditioned" patient, the administration of IVIg, the transmission of pig CMV, and of the difficulties in interpreting myocardial biopsy findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.