Evidence map›Paper›PMID 35942560›Full record

ArticleThe Journal of international medical research2022

Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4

Peng Jin, Hongping Zhang, Xilin Zhu, Kaiyue Sun, Tao Jiang, Li Shi, Lili Zhi, Hailing Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Peng JinDepartment of Otolaryngology, The Second Hospital of Shandong University, Jinan, China.
Hongping ZhangDepartment of Otolaryngology, The Second Hospital of Shandong University, Jinan, China.
Xilin ZhuDepartment of Otolaryngology, Central Hospital of Lijin, Dongying, China.
Kaiyue SunDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Tao JiangDepartment of Otolaryngology, YingCheng Hospital, Yantai, China.
Li ShiDepartment of Otolaryngology, The Second Hospital of Shandong University, Jinan, China.
Lili ZhiDepartment of Allergy, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China.ORCID https://orcid.org/0000-0001-5664-9974
Hailing ZhangDepartment of Otolaryngology, The Second Hospital of Shandong University, Jinan, China.
Second Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to discover potential circulating genes and non-coding molecules (micro RNA [miRNA] and circular RNA [circRNA]) in CD4

methodsMicroarray data of GSE50223 were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) during and outside the pollen season were analyzed using R software and by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analyses. The protein-protein interactions, modules, miRNAs targeting DEGs, merged miRNA-DEG networks, and circRNAs targeted with miRNAs were further analyzed.

resultsWe identified 211 DEGs during the pollen season and eight DEGs outside the season, of which only

conclusionsSome genes, miRNAs, and circRNAs in CD4

Indexed as

MicroRNAsRhinitis, Allergic, SeasonalCD4-Positive T-LymphocytesComputational BiologyGene Expression ProfilingGene Regulatory NetworksHumansRNA, CircularRNA, MessengerT-LymphocytesMicroRNAsMIRN29B1 microRNA, humanRNA, CircularRNA, MessengerAllergic rhinitisbioinformaticsCD4+ T cellcircular RNAmicroRNApathogenesis

Identifiers

PMID35942560
PMCPMC9373143
OpenAlexW4291396190

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.