ArticleNature and science of sleep2022
Functional Connectivity Disturbances of the Locus Coeruleus in Chronic Insomnia Disorder.
Article in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Is There a Relationship Between Movement and Sleep Disturbances in Essential Tremor?Brain sciences · 2026Article
- Neuropsychiatric, stress-related symptoms and essential tremor clinical variability.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Resting-State Functional Connectivity Alterations in Insomnia Disorder: A Systematic Review of Studies Published from 2020 to July 2025.Nature and science of sleep · 2026Review
- Multimodal neuroimaging of locus coeruleus-default mode network connectivity for predicting dexmedetomidine response in chronic insomnia disorder.Frontiers in psychiatry · 2026Article
- Diagnosis of adolescent depression with sleep disorder based on network topological attributes and functional connectivity.BMC psychiatry · 2025Article
- Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.BMC medicine · 2025Article
- Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea.Scientific reports · 2023Article
- The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation.Frontiers in neuroscience · 2023Article
- The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI.Frontiers in neuroscience · 2023Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In recent years, people have gained a profound understanding of chronic insomnia disorder (CID), but the pathophysiological mechanism of CID is still unclear. There is some evidence that the locus coeruleus (LC) is involved in the regulation of wakefulness in CID, but there have been few studies using brain functional imaging. The purpose of this study was to evaluate the resting-state functional connectivity (FC) between the LC and other brain voxels in CID and whether these abnormal FC are involved in the regulation of wakefulness. Methods: A total of 49 patients with chronic insomnia disorder and 47 healthy controls (HC) matched for gender, age, and education were examined with rs-fMRI in this study. The LC was selected as the region of interest, and then seed-based analysis was conducted on the LC and other voxels to obtain the brain regions with abnormal FC. The correlation between the FC value of the abnormal connection area and the clinical scale score was analyzed. Results: Compared with the HC, the FC between the LC and right precuneus, right posterior cingulate cortex, left middle temporal gyrus, left calcarine, and right superior orbitofrontal cortex was significantly enhanced (p < 0.05, FDR correction), and the functional connectivity signal value between the locus coeruleus and left middle temporal gyrus was positively correlated with the Self-Rating Depression Scale (p = 0.021). Conclusion: The abnormal FC between the LC and multiple brain regions may contribute to a better understanding of the neurobiological mechanism of CID.
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