Protocol for spike-triggered closed-loop auditory stimulation during sleep in patients with epilepsy.

Hong-Viet V Ngo, Jan Born, Jens G Klinzing

Abstract read

In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hong-Viet V NgoDepartment of Psychology, University of Lübeck, 23562 Lübeck, Germany; Center for Brain, Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany. Electronic address: ho.ngo@uni-luebeck.de.

Jan BornInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; Centre for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany.

Jens G KlinzingInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; Centre for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany; Bit&Brain Technologies SL (Bitbrain), 50008 Zaragoza, Spain. Electronic address: jens.klinzing@uni-tuebingen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several epilepsies are characterized by interictal spikes in the electroencephalogram occurring preferentially during sleep. We present a closed-loop auditory stimulation protocol with potential for treating sleep epilepsies. We describe the pre-sleep preparations, sleep recordings, the auditory stimulation, in which tones are triggered upon spike detection, and post-sleep procedures. This protocol has been shown to decrease likelihood and amplitude of subsequent spikes in patients with BECTS (Benign epilepsy with centrotemporal spikes) and can be applied to study non-pharmacological treatments of sleep epilepsies. For complete details on the use and execution of this protocol, please refer to Klinzing et al. (2021).

Indexed as

Epilepsy, RolandicAcoustic StimulationElectroencephalographyHumansSleepBehaviorClinical ProtocolCognitive NeuroscienceNeuroscience

Identifiers

PMID35942345

DOI10.1016/j.xpro.2022.101505

PMCPMC9356163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.