ArticleiScience2022
Joint inference of ancestry and genotypes of parents from children.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A general approach for inferring the ancestry of recent ancestors of an admixed individual.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we address a problem: can we perform ancestry inference for parents from one or more children's DNA samples? That is, suppose the parents' genomes consist of segments of different ancestry, and our goal is inferring parental ancestry and at the same time, calling parental genotypes from given children's genetic data. Such ancestry inference may provide insights into recent ancestors from children's genomes, and potentially has applications in understanding genetic traits. At present, there exists no method for this inference problem. We present parMix, a method based on hidden Markov model (HMM) that can jointly infer parental ancestry and call parental genotypes from data of a small number of children. Simulation results show that parMix performs well in practice. It can provide reasonably accurate parental inference given data from a small number (say three) of children. parMix becomes more accurate when data from more children are used.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.