Evidence map›Paper›PMID 35941867›Full record

ArticleCurrent research in structural biology2022

Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector

Arianna Esposito Verza, Riccardo Miggiano, Fabrizio Lombardo, Carmine Fiorillo, Bruno Arcà, Beatrice Purghé, Erika Del Grosso, Ubaldina Galli, Menico Rizzi, Franca Rossi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Arianna Esposito VerzaUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Riccardo MiggianoUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Fabrizio LombardoSapienza University of Rome, Department of Public Health and Infectious Diseases - Division of Parasitology, Piazzale Aldo Moro, 5, Rome, Italy.
Carmine FiorilloSapienza University of Rome, Department of Public Health and Infectious Diseases - Division of Parasitology, Piazzale Aldo Moro, 5, Rome, Italy.
Bruno ArcàSapienza University of Rome, Department of Public Health and Infectious Diseases - Division of Parasitology, Piazzale Aldo Moro, 5, Rome, Italy.
Beatrice PurghéUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Erika Del GrossoUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Ubaldina GalliUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Menico RizziUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Franca RossiUniversity of Piemonte Orientale, DSF Department of Pharmaceutical Sciences, Largo Donegani, 2, Novara, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITDepartment of Public Health · MM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The temporary or permanent chemical modification of biomolecules is a crucial aspect in the physiology of all living species. However, while some modules are well characterised also in insects, others did not receive the same attention. This holds true for sulfo-conjugation that is catalysed by cytosolic sulfotransferases (SULT), a central component of the metabolism of endogenous low molecular weight molecules and xenobiotics. In particular, limited information is available about the functional roles of the mosquito predicted enzymes annotated as SULTs in genomic databases. The herein described research is the first example of a biochemical and structural study of a SULT of a mosquito species, in general, and of the malaria vector

Indexed as

Crystal structureCytosolic sulfotransferaseDifferential mRNA expressionMosquitoReproductive systemSULT

Identifiers

PMID35941867
PMCPMC9356239
OpenAlexW4286512443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.