Evidence map›Paper›PMID 35941857›Full record

ArticleClinical, cosmetic and investigational dermatology2022

Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus.

Jun Fang Chen, Xue Mei Zhang, Kiran Sanjel, Juan Zhang, Cong Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical, cosmetic and investigational dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Comprehensive Insight into Lichen Planus Immunopathogenesis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jun Fang ChenThe Dermatology and Venereology Department, The Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, People's Republic of China.
Xue Mei ZhangThe Dermatology and Venereology Department, The Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, People's Republic of China.
Kiran SanjelThe Dermatology and Venereology Department, The Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, People's Republic of China.
Juan ZhangClinical Medical School, Inner Mongolia Minzu University, Tongliao, People's Republic of China.
Cong MaThe Dermatology and Venereology Department, The Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, People's Republic of China.
Minzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The purpose of this study was to explore the expression of TNF-α and NF-κB/p65 in Lichen planus skin lesions and their correlation with the pathogenesis of Lichen planus. Patients and Methods: The case group consisted of 30 individuals diagnosed with LP based on clinical and histopathologic examination. The control group consisted of 10 individuals from an Orthopedic Department with normal skin. TNF-α and NF-κB/p65 expression in skin tissue samples was detected by immunohistochemistry. Results: The immunohistochemical results showed that TNF-α and NF-κB/p65 expression levels were significantly higher in LP skin lesions than normal skin tissues (P ≤ 0.05). Positive TNF-α staining mainly occurred in the cytoplasm of keratinocytes of the stratum granulosum, stratum spinosum, and stratum basale in the epidermis and lymphocytes in the superficial dermis. Positive NF-κB/p65 staining mainly occurred in the nucleus and cytoplasm of keratinocytes of the stratum spinosum and stratum basale in the epidermis and lymphocytes in the superficial dermis. Conclusion: TNF-α and NF-κB/p65 are overexpressed in cutaneous LP. The two are positively correlated in LP, suggesting that they both play essential roles in the pathogenesis of LP.

Indexed as

immunohistochemistrylichen planusNF-κB/p65stainingTNF-α

Identifiers

PMID35941857
PMCPMC9356624
OpenAlexW4289527209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.