Evidence map›Paper›PMID 35941658›Full record

ReviewMolecular brain2022

Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection.

Vaishnavi Sundar, Jay P McLaughlin, Thangavel Samikkannu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. A new perspective on HIV: effects of HIV on brain-heart axis.Frontiers in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vaishnavi SundarDepartment of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, 1010 W Avenue B, Kingsville, 78363, TX, USA.
Jay P McLaughlinDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, 32611, FL, USA.
Thangavel SamikkannuDepartment of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, 1010 W Avenue B, Kingsville, 78363, TX, USA. thangavel@tamu.edu.ORCID 0000-0001-5071-056X
Texas A&M University – Kingsville · USUniversity of Florida · US

Funding

Cocaine and HIV Influence Mitochondrial Epigenetics in Astrocytic NetworksR01DA044872 · NIDA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI THANGAVEL, SAMIKKANNU · 2017 to 2021
$2.3M
NIDA NIH HHS R01 DA044872
6 · The paper itself

Abstract

HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes induced by viral infection might play a critical role in virus-host interactions in HIV infection. The mitochondrial epigenetic mechanism, predominantly Nt acetylation, holds HIV immunopathogenesis and is vastly unexplored. The challenge is to single out the specific pathological role of NAT changes in HIV-associated neurodegeneration. Therefore, this nano review aims to shine light on Nt acetylation in HIV pathogenesis, which we believe can lead to effective future therapeutic strategies against HIV-associated neurodegeneration.

Indexed as

HIV InfectionsN-Terminal AcetyltransferasesAcetylationEpigenesis, GeneticHumansProtein Processing, Post-TranslationalN-Terminal AcetyltransferasesEpigeneticsHIVNeurodegenerationNt-acetylationNt acetyltransferase

Identifiers

PMID35941658
PMCPMC9358866
OpenAlexW4290615482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.