ReviewBMC endocrine disorders2022
The association of uric acid with the development of thyroid nodules: a retrospective cohort study.
Review in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Machine learning model for differentiating malignant from benign thyroid nodules based on the thyroid function data.BMJ open · 2025Article
- Thyroid disease as a comorbidity in inflammatory rheumatic diseases.Rheumatology international · 2025Review
- Risk factors for thyroid nodules in a health examination population: a cross-sectional study and development of a simplified predictive model.Frontiers in endocrinology · 2025Article
- Pituitary-Thyroid Hormones and Related Indices in Euthyroid Type 2 Diabetes: Association With Thyroid Nodules.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The association between metal element levels and thyroid nodules in oilfield workers: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Uric Acid Status in Subclinical Hypothyroidism.EJIFCC · 2024Review
- Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators.Frontiers in endocrinology · 2024Article
- Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study.International journal of endocrinology · 2024Article
- Article
- Do metabolic factors increase the risk of thyroid cancer? a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUric acid was found to have a positive correlation with thyroid nodules in the cross-sectional studies recently. We aimed to conduct a retrospective cohort study to investigate whether uric acid is a risk factor for the development of thyroid nodules.
methodsWe reviewed the data of individuals who attended the medical check-ups in our hospital from 2010 to 2019. A total of 6587 adults without thyroid nodules at baseline were enrolled in this study. Logistic regression with or without restricted cubic spline function was used to investigate the non-linear or linear association between uric acid and thyroid nodules, respectively.
resultsBaseline characteristics showed that subjects mainly consisted of the healthy, young population. After fully adjusting for the potential confounders, such as age, sex, metabolic and inflammatory indicators, hepatic and renal function, a logistic restricted cubic spline regression model suggested that uric acid had a significant association (P = 0.028) with the development of thyroid nodules, but the association was not non-linear (P = 0.516). The results indicate that the association between them is linear, which was demonstrated by a logistic regression model, in which the odds ratio of uric acid per 100 mmol/L was 1.137 (P = 0.004). Age, sex, diastolic blood pressure, fasting blood sugar, and blood monocyte were found to be risk factors for thyroid nodules as well.
conclusionUric acid is an independent risk factor for the formation of thyroid nodules. This finding warrants attention to this risk factor in apparently healthy adults.
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