ArticleBMC geriatrics2022
Nutrition mediates the relationship between number of teeth and sarcopenia: a pathway analysis.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Oral-Sarcopenia nexus in health disparities: chewing and blood mediated pathways in a Chinese aging cohort.BMC oral health · 2025Observational
- Explaining the Association Between Number of Teeth and Frailty in Older Chinese Adults: The Chain Mediating Effect of Nutritional Status and Cognitive Function.International journal of nursing practice · 2025Article
- Reduced Mastication Is Associated With Dynapenia Markers in Patients With Cirrhosis: A Cross-Sectional Study.International journal of hepatology · 2025Article
- Association between number of functional teeth and physical function among community-dwelling older adults: Korean Frailty and Aging Cohort Study.BMC geriatrics · 2024Article
- Association of periodontitis with handgrip strength and skeletal muscle mass in middle-aged US adults from NHANES 2013-2014.Aging clinical and experimental research · 2023Article
- Association of oral status with frailty among older adults in nursing homes: a cross-sectional study.BMC oral health · 2023Article
- What Is the Relationship between the Chewing Ability and Nutritional Status of the Elderly in Korea?Nutrients · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe relationship between the number of teeth and sarcopenia remains poorly investigated. Although nutrition plays an important role in maintaining bone and muscle health, the complex relationship between number of teeth and nutrition in the pathogenesis of sarcopenia remains to be elucidated.
methodsA large multi-ethnic sample of 4149 participants aged over 50 years old from West China Health and Aging Trend (WCHAT) study was analyzed. We examined the associations between number of teeth with nutritional status and sarcopenia, and the mediating role of nutrition in the association between number of teeth and sarcopenia. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019. We assessed nutrition using Mini Nutrition Assessment-Short Form (MNA-SF) scale. Direct relationships between number of teeth, nutrition and sarcopenia were assessed using multiple linear regression. Mediation models and structural equation model (SEM) pathway analysis were used to test the mediating role of nutrition in the relationship between number of teeth and sarcopenia.
resultsOf 4149 participants aged 50 years old or older, the prevalence of sarcopenia was 22.5, 9.0% for moderate sarcopenia, and 13.5% for severe sarcopenia, respectively. Regression analysis indicated a total association between number of teeth (β = - 0.327, 95% CI - 0.471 to - 0.237, p < 0.001) and sarcopenia. After adjusted MNA-SF scores, the association between number of teeth and sarcopenia was still significant (β = - 0.269, 95% CI - 0.364 to - 0.175, p < 0.001), indicating a partial mediation effect of nutrition. Mediation analysis verified nutrition partially mediate the associations between number of teeth and sarcopenia (indirect effect estimate = - 0.0272, bootstrap 95% CI - 0.0324 to - 0.0222; direct effect estimate = - 0.0899, bootstrap 95% CI - 0.1049 to - 0.0738). And this mediation effect was through impacting SMI (indirect effect estimate = - 0.0283, bootstrap 95% CI - 0.0336 to - 0.0232) and grip strength (indirect effect estimate = - 0.0067, bootstrap 95% CI - 0.0094 to - 0.0043). Structural equation model (SEM) framework pathway analysis confirmed the association between number of teeth, nutrition, and sarcopenia.
conclusionsOur findings indicated that sarcopenia was associated with number of teeth and poorer nutritional status, with nutrition partially mediating the association between number of teeth and sarcopenia. Our findings supported early nutritional assessment and intervention in oral health to mitigate the risk of sarcopenia.
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