Evidence map›Paper›PMID 35941548›Full record

Trial reportBMC anesthesiology2022

Comparative effect of transforaminal injection of Magnesium sulphate versus Ozone on oxidative stress biomarkers in lumbar disc related radicular pain.

Wael Fathy, Mona Hussein, Raghda E Ibrahim, Manar M Abdel-Aziz, Shaden Adel, Shaimaa H Soliman, Hatem Elmoutaz, Mohamed Abdelkader

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wael FathyDepartment of Anaesthesia, Surgical ICU and Pain Management, Beni-Suef University, Beni-Suef, Egypt.
Mona HusseinDepartment of Neurology, Beni-Suef University, Beni-Suef, Egypt. mona.neuro@yahoo.com.ORCID 0000-0002-7478-7008
Raghda E IbrahimDepartment of Clinical and Chemical pathology, Beni-Suef University, Beni-Suef, Egypt.
Manar M Abdel-AzizDepartment of Clinical and Chemical pathology, Beni-Suef University, Beni-Suef, Egypt.
Shaden AdelDepartment of Psychiatry, Cairo University, Cairo, Egypt.
Shaimaa H SolimanDepartment of Neurology, Cairo University, Cairo, Egypt.
Hatem ElmoutazDepartment of Anaesthesia, Surgical ICU and Pain Management, Beni-Suef University, Beni-Suef, Egypt.
Mohamed AbdelkaderDepartment of Anaesthesia, Surgical ICU and Pain Management, Beni-Suef University, Beni-Suef, Egypt.
Beni-Suef University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to investigate the effect of transforaminal injection of Magnesium sulphate versus Ozone on pain intensity, functional disability and the oxidative stress biomarkers; superoxide dismutase (SOD) and Glutathione (GSH) in patients with lumbar disc prolapse.

methodsThis randomized controlled trial was conducted on 135 patients having symptomatic lumbar disc prolapse, received either transforaminal injection of Magnesium sulphate with steroids, Ozone with steroids, or steroids alone. Assessment of pain severity and functional disability were done before intervention, 2 weeks, 1, 3, and 6 months after intervention. Serum SOD and GSH were measured for all included patients before and 2 weeks after intervention.

resultsThere was a statistically significant improvement in pain intensity and functional disability 2 weeks after intervention in the three groups, but at 1-month and 3-months after intervention, the significant improvement was in Mg sulphate and Ozone groups only. At 6-months follow up, Mg sulphate group only showed a significant improvement. There was a statistically significant increase in SOD and GSH serum levels, 2-weeks after intervention in both Magnesium sulphate (P-value = 0.002, 0.005 respectively) and ozone groups (P-value < 0.001, < 0.001), but there was no statistically significant change in SOD and GSH serum levels in control group.

conclusionTransforaminal injection of Mg sulphate in patients with lumbar disc prolapse causes significant long-term improvement (up to 6 months) in pain intensity and functional disability. The serum levels of SOD and GSH were significantly increased at 2 weeks following both transforaminal injection of Mg sulphate and ozone.

Indexed as

Intervertebral Disc DisplacementOzoneBiomarkersHumansInjections, EpiduralLumbar VertebraeMagnesium SulfateOxidative StressPainProlapseSteroidsSuperoxide DismutaseTreatment OutcomeBiomarkersMagnesium SulfateOzoneSteroidsSuperoxide DismutaseGSHLumbar disc prolapseMg sulphateOzoneSOD

Identifiers

PMID35941548
PMCPMC9358797
OpenAlexW4290612975

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.