ArticleBMC gastroenterology2022
Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whose natural history was closely followed by ultrasound.
Article in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Intracholecystic Papillary Neoplasms (ICPNs): Systematic Review and Meta-analysis of Epidemiological, Diagnostic, Immunohistochemical, and Clinical Features.Annals of surgical oncology · 2026Pooled it
- Article
- Progressive growth of a small gallbladder polyp diagnosed as intracholecystic papillary neoplasm: a case report.BMC gastroenterology · 2026Article
- CT imaging and clinicopathologic differentiation of intracholecystic papillary neoplasm with associated invasive carcinoma and conventional gallbladder adenocarcinoma.Abdominal radiology (New York) · 2026Article
- Article
- Intracholecystic papillary neoplasm: A case report.International journal of surgery case reports · 2025Article
- Surgical Case of Metachronous Occurrence of Intracholecystic Papillary Neoplasm in the Remnant Cystic Duct 19 Years after Cholecystectomy.Surgical case reports · 2025Article
- Article
- A Rare Finding of Incidental Intracholecystic Papillary Neoplasm Following Acute Cholecystitis Management.Cureus · 2023Article
- Extensively Invasive Gallbladder Cancer from Intracholecystic Papillary Neoplasm Treated with Pylorus-Preserving Pancreaticoduodenectomy and Extended Cholecystectomy: A Case Report and Literature Review.Case reports in surgery · 2023Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICPN, in which the papillary lesion was observed transforming from small and benign to malignant using abdominal ultrasound (AUS) over 2 years during routine health checks. A 44-year-old man underwent a routine health check-up. The initial AUS showed a small sessile polyp in the gallbladder, which enlarged slightly at the next AUS, a year later. In the third year, the polypoid lesion enlarged markedly, with a maximum diameter of 10 × 9 × 7 mm. Therefore, a laparoscopic cholecystectomy was performed. Microscopically, the 10 mm tumor had intracytoplasmic mucus, and a clear cytoplasm compatible with gastric-type features. Immunohistochemical analysis showed positive staining of atypical cells for MUC6 and PAS. These findings led to the diagnosis of ICPN with high-grade intraepithelial neoplasia of the gastric type. In conclusion, sessile polyps with rapid growth might be a crucial finding in the early stage of ICPN.
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