Evidence map›Paper›PMID 35941318›Full record

ArticleSleep & breathing = Schlaf & Atmung2023

An interim oral appliance as a screening tool during drug-induced sleep endoscopy to predict treatment success with a mandibular advancement device for obstructive sleep apnea.

Pien Fenneke Nicole Bosschieter, Julia A M Uniken Venema, Patty E Vonk, Madeline J L Ravesloot, Joost W Vanhommerig, A Hoekema, Joanneke M Plooij, F Lobbezoo, Nico de Vries

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. [Dynamic assessment of upper airway in obstructive sleep apnea patients with a focus on drug-induced sleep endoscopy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Pien Fenneke Nicole BosschieterDepartment of Otorhinolaryngology, Head and Neck Surgery, OLVG, Amsterdam, the Netherlands. pfnb@stanford.edu.ORCID 0000-0001-7964-3225
Julia A M Uniken VenemaDepartment of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Patty E VonkDepartment of Otorhinolaryngology - Head and Neck Surgery, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands.
Madeline J L RaveslootDepartment of Otorhinolaryngology, Head and Neck Surgery, OLVG, Amsterdam, the Netherlands.
Joost W VanhommerigDepartment of Research and Epidemiology, OLVG, Amsterdam, the Netherlands.
A HoekemaDepartment of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Joanneke M PlooijDepartment of Oral and Maxillofacial Surgery, OLVG, Amsterdam, the Netherlands.
F LobbezooDepartment of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Nico de VriesDepartment of Otorhinolaryngology, Head and Neck Surgery, OLVG, Amsterdam, the Netherlands.
OLVG · NLAcademic Center for Dentistry Amsterdam · NLAmsterdam University Medical Centers · NLUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies have shown a wide range of efficacy (29 to 71%) of a mandibular advancement device (MAD) in the treatment of obstructive sleep apnea (OSA). Currently, the ability to preselect suitable patients for MAD therapy based on individual characteristics related to upper airway collapsibility is limited. We investigated if the use of non-custom interim MAD during drug-induced sleep endoscopy (DISE) could be a valuable screening tool to predict MAD treatment outcome.

methodsIn a single-center prospective study including a consecutive series of patients with OSA, we compared DISE outcomes with a MAD in situ with polysomnography results after 3 months of using the same MAD that was used during DISE.

resultsOf 41 patients who completed the study, the median apnea-hypopnea index (AHI) was 16.0 events/h [IQR 7.4-23.4]. Respiratory outcomes on polysomnography, including apnea index (AI), total AHI, AHI in supine position, and oxygen desaturation index, all significantly improved after 3 months of MAD treatment. With complete improvement of the upper airway obstruction with the MAD in situ during DISE in supine position, patients were 6.3 times more likely to be a responder to MAD treatment compared to patients with a persisting complete obstruction, although not statistically significant (OR 6.3; 95%CI 0.9-42.7; p = 0.060).

conclusionThe potential predictive value with regard to MAD therapy outcomes of the use of an interim MAD during DISE would be an important finding, since the prediction of MAD therapy outcome is of great clinical and scientific interest. A study with a larger cohort should be performed to further investigate our findings.

Indexed as

Mandibular AdvancementSleep Apnea, ObstructiveEndoscopyHumansOcclusal SplintsProspective StudiesSleepTreatment OutcomeDrug-induced sleep endoscopyMandibular advancement deviceObstructive sleep apneaSleep-disordered breathingTreatment success

Identifiers

PMID35941318
PMCPMC9360646
OpenAlexW4290694825

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.