Evidence map›Paper›PMID 35941207›Full record

ReviewPediatric radiology2022

Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.

Ricardo Restrepo, David Zahrah, Liset Pelaez, H Thomas Temple, James W Murakami

Open access · hybridAbstract readReview
In one paragraph

Review in Pediatric radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 135 citations in OpenAlex.

  1. [Primary bone tumors of the spine].Radiologie (Heidelberg, Germany) · 2026
    Review
  2. Spinal aneurysmal bone cysts in children - institutional chart review and recommendation for treatment.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  3. Intraosseous tumours of the knee.Skeletal radiology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Musculoskeletal Intervention in Children: An Update.Cardiovascular and interventional radiology · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Management of spinal aneurysmal bone cyst: A case report.Surgical neurology international · 2026
    Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ricardo RestrepoDepartment of Radiology, Nicklaus Children's Hospital, Miami, FL, USA.ORCID http://orcid.org/0000-0001-5131-5975
David ZahrahSchool of Arts and Sciences, Washington University, St. Louis, MO, USA.
Liset PelaezDepartment of Pathology, Nicklaus Children's Hospital, Miami, FL, USA.
H Thomas TempleDepartment of Orthopedic Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
James W MurakamiDepartment of Radiology, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. James.murakami@nationwidechildrens.org.
Miami Children's Hospital · USNationwide Children's Hospital · USUniversity of Miami · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneurysmal bone cyst (ABC) is a benign but locally aggressive lesion that predominantly affects children and young adults. ABC, which accounts for approximately 70% of the cases, is now recognized to be a true neoplasm, whereas ABC-like changes associated to other bone neoplasms (also referred in the literature as secondary ABC) accounts for the remaining 30%. The solid variant of ABC is also considered a true neoplasm but is rare. ABC can involve any bone in the body, and although it has a metaphyseal preference, it can involve any part of a bone and soft tissues. As with any bone tumor, the initial evaluation of ABCs should be done with radiographs followed by magnetic resonance imaging or less frequently computed tomography for further characterization. The imaging appearance of ABC is variable; however, a lytic and expansile lesion with fluid-fluid levels is the most common presentation. The main differential diagnosis of an ABC in the pediatric population is unicameral bone cyst (UBC) and telangiectatic osteosarcoma, therefore a biopsy is recommended before treatment. The therapeutic options of ABC range from curettage with or without adjuncts such as phenol, liquid nitrogen, argon laser and bone grafting or bone substitutes to more recently employed alternatives such as image-guided sclerotherapy with various sclerosing agents and monoclonal antibodies (e.g., Denosumab).

Indexed as

Bone CystsBone Cysts, AneurysmalBone NeoplasmsOsteosarcomaChildHumansTomography, X-Ray ComputedYoung AdultAneurysmal bone cystBoneChildrenComputed tomographyMagnetic resonance imagingRadiographySclerotherapy

Identifiers

PMID35941207
PMCPMC9360065
OpenAlexW4291019731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.