ArticleNature ecology & evolution2022
Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 59 citations in OpenAlex.
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- Neural connectome of the ctenophore statocyst.eLife · 2026Article
- The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution.Nature reviews. Neuroscience · 2026Review
- Hydra at the Crossroads of Evolution: Insights into Cell-type Diversification, Regeneration, and Epigenetic Regulation.Results and problems in cell differentiation · 2026Review
- Early transitions in the evolution of cognition.History and philosophy of the life sciences · 2025Article
- Beyond synapses: cytoplasmic connections in brain function and evolution.Biological reviews of the Cambridge Philosophical Society · 2025Review
- AnOpen biology · 2025Article
- The neuropeptidomes of the sea cucumbers Stichopus cf. horrens and Holothuria scabra.Scientific reports · 2025Article
- Evolutionary scenarios for the specific recognition of nonhomologous endogenous peptides by G protein-coupled receptor paralogs.The Journal of biological chemistry · 2025Article
- Retention order prediction of peptides containing non-proteinogenic amino acids.Bioinformatics advances · 2025Article
- Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis.Nature communications · 2024Article
- Large-scale deorphanization ofeLife · 2024Article
- The lncRNA lnc_AABR07044470.1 promotes the mitochondrial-damaged inflammatory response to neuronal injury via miR-214-3p/PERM1 axis in acute ischemic stroke.Molecular biology reports · 2024Article
- Neuromuscular organization of the benthic ctenophore, Vallicula multiformis.Zoological letters · 2024Article
- Recording Cilia Activity in Ctenophores.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Analysis and Visualization of Single-Cell Sequencing Data with Scanpy and MetaCell: A Tutorial.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Brief History of Ctenophora.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Evolution of the Nervous System Extrapolated from Ctenophore and the Resurrection of Golgi's Reticular Theory?Neuroscience bulletin · 2023Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
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17 authors at 4 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The evolutionary origins of neurons remain unknown. Although recent genome data of extant early-branching animals have shown that neural genes existed in the common ancestor of animals, the physiological and genetic properties of neurons in the early evolutionary phase are still unclear. Here, we performed a mass spectrometry-based comprehensive survey of short peptides from early-branching lineages Cnidaria, Porifera and Ctenophora. We identified a number of mature ctenophore neuropeptides that are expressed in neurons associated with sensory, muscular and digestive systems. The ctenophore peptides are stored in vesicles in cell bodies and neurites, suggesting volume transmission similar to that of cnidarian and bilaterian peptidergic systems. A comparison of genetic characteristics revealed that the peptide-expressing cells of Cnidaria and Ctenophora express the vast majority of genes that have pivotal roles in maturation, secretion and degradation of neuropeptides in Bilateria. Functional analysis of neuropeptides and prediction of receptors with machine learning demonstrated peptide regulation of a wide range of target effector cells, including cells of muscular systems. The striking parallels between the peptidergic neuronal properties of Cnidaria and Bilateria and those of Ctenophora, the most basal neuron-bearing animals, suggest a common evolutionary origin of metazoan peptidergic nervous systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.