Evidence map›Paper›PMID 35940821›Full record

ArticleLupus science & medicine2022

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4

Ruth L Esser, Carolin Brück, Jan Thiele, Viktoria Golumba-Nagy, Anja Meyer, Eva Steinbach-Knödgen, Shuaifeng Yan, Carola Tho Pesch, David Stahl, Joanna Schiller and 1 more

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In one paragraph

Article in Lupus science & medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ruth L EsserDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Carolin BrückDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Jan ThieleDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Viktoria Golumba-NagyDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Anja MeyerDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.ORCID 0000-0001-9904-5070
Eva Steinbach-KnödgenDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Shuaifeng YanDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Carola Tho PeschDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
David StahlDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Joanna SchillerDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
David M KoflerDepartment I of Internal Medicine, University Hospital Cologne, Cologne, Germany david.kofler@uk-koeln.de.ORCID 0000-0001-6164-3980
University Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSLE is an autoimmune disease with a complex pathogenesis. T-cell infiltration into organs contributes to inflammation and organ damage in SLE. Recently, G-protein signalling modulator 2 (GPSM2) has been shown to be implicated in T-cell migration.

methodsWe analysed the expression levels of GPSM2 and of a truncated isoform of GPSM2 containing the GoLoco motif region in CD4

resultsOur experiments revealed comparable levels of GPSM2 in CD4

conclusionsA truncated GPSM2 isoform containing the GoLoco motif region is upregulated in CD4

Indexed as

Lupus Erythematosus, SystemicCD4-Positive T-LymphocytesCell MovementHumansIntracellular Signaling Peptides and ProteinsProtein IsoformsT-LymphocytesGPSM2 protein, humanIntracellular Signaling Peptides and ProteinsProtein Isoformsautoimmunitylupus erythematosus, systemicT-lymphocytes, helper-inducer

Identifiers

PMID35940821
PMCPMC9364394
OpenAlexW4290673098

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.