Evidence map›Paper›PMID 35940477›Full record

ArticleOphthalmology. Retina2023

Extramacular Drusen and Progression of Age-Related Macular Degeneration: Age Related Eye Disease Study 2 Report 30.

Amitha Domalpally, Bohan Xing, Jeong W Pak, Elvira Agrón, Fredrick L Ferris, Traci E Clemons, Emily Y Chew

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Age-Related Macular Degeneration, a Mathematically Tractable Disease.Investigative ophthalmology & visual science · 2024
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amitha DomalpallyWisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address: domalpally@wisc.edu.
Bohan XingWisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Jeong W PakWisconsin Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Elvira AgrónDivision of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland.
Fredrick L FerrisOphthalmic Research Consultants, LLC, Waxhaw, North Carolina.
Traci E ClemonsThe EMMES Corporation, Rockville, Maryland.
Emily Y ChewDivision of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland.

Funding

AGE RELATED EYE DISEASE STUDY - COORDINATING CENTERN01EY002127 · NEI · EMMES CORPORATION · PI EDERERI, FRED · 1990 to 2000
$1.7M
The Age-Related Eye Disease Study 2 (AREDS2)ZIAEY000485 · NEI · NATIONAL EYE INSTITUTE · PI CHEW, EMILY Y · 2009 to 2015
$990k
Age-Related Eye Disease Follow-up Study (AREDS) Follow-up StudyZIAEY000489 · NEI · NATIONAL EYE INSTITUTE · PI CHEW, EMILY Y · 2009 to 2025
$639k
Intramural NIH HHS ZIA EY000485NEI NIH HHS N01 EY002127NEI NIH HHS N01 EY060003NIH HHS HHSN260200600007C
6 · The paper itself

Abstract

purposeTo identify the prevalence of extramacular drusen and their role in the progression of age-related macular degeneration (AMD).

designRetrospective analysis of a prospective cohort study.

participantsThe study was conducted in 4168 eyes (2998 participants) with intermediate AMD in one or both eyes enrolled in the Age-Related Eye Disease Study 2 (AREDS2), a 5-year multicenter study of nutritional supplements.

methodsBaseline 3-field 30-degree color photographs were evaluated for drusen characteristics outside the macular grid, including size, area, and location. The characteristics of extramacular drusen were compared with those of drusen within the macula.

main outcome measuresProgression rates to late AMD.

resultsAlthough extramacular drusen were observed in 3624 (86.9%) eyes, they represented a small area (< 0.5 mm

conclusionsExtramacular drusen are commonly observed in eyes with AMD and are more frequent with an increasing drusen burden within the macula. In eyes with intermediate AMD, extramacular drusen do not confer additional risk to previously identified risk factors in progression to late AMD.

Indexed as

Macular DegenerationRetinal DrusenAngiogenesis InhibitorsHumansProspective StudiesRetrospective StudiesVascular Endothelial Growth Factor AVisual AcuityWet Macular DegenerationAngiogenesis InhibitorsVascular Endothelial Growth Factor AAMDARMDDrusenExtramacular drusenGeographic atrophyLate AMDMidperipheral drusenNeovascular AMD

Identifiers

PMID35940477
PMCPMC9899297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.