ArticleNature2022
Autoantibody mimicry of hormone action at the thyrotropin receptor.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists.bioRxiv : the preprint server for biology · 2026Article
- Conformational equilibria in the activation of cystine-knot hormone receptors.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Nanobodies unlock new mechanisms to target G protein-coupled receptors.Molecular pharmacology · 2026Review
- The thyrotropin receptor structure and interactions with autoantibodies.European thyroid journal · 2025Review
- Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.Nature communications · 2025Article
- Expression, immunogenicity and clinical significance analysis of thyroid‑stimulating hormone receptor fusion proteins.Molecular medicine reports · 2025Article
- Unravelling the pathogenic mechanisms in Graves' orbitopathy.European thyroid journal · 2025Review
- G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers.MedComm · 2025Review
- TSHR in thyroid cancer: bridging biological insights to targeted strategies.European thyroid journal · 2025Review
- PET imaging of differentiated thyroid cancer with thyrotropin-alfa.Scientific reports · 2025Article
- Deconvolution to restore cryo-EM maps with anisotropic resolution.Research square · 2025Article
- Deconvolution to restore cryo-EM maps with anisotropic resolution.bioRxiv : the preprint server for biology · 2025Article
- Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling.Nature communications · 2025Article
- Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function.Nature communications · 2024Article
- Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.Nature structural & molecular biology · 2024Article
- An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers.The Journal of clinical endocrinology and metabolism · 2024Article
- Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism.Nature reviews. Endocrinology · 2024Review
- GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.Nature structural & molecular biology · 2024Article
- Self Fourier shell correlation: properties and application to cryo-ET.Communications biology · 2024Article
- Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model.JCI insight · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Bryan Faust *Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4126-6409
Christian B Billesbølle *Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8084-1552
Carl-Mikael SuomivuoriDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2445-8791
Isha SinghDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Kaihua ZhangDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
Nicholas HoppeDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Antonio F M PintoMass Spectrometry Core for Proteomics and Metabolomics, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jolene K DiedrichMass Spectrometry Core for Proteomics and Metabolomics, Salk Institute for Biological Studies, La Jolla, CA, USA.
Yagmur MuftuogluStanford University School of Medicine, Stanford, CA, USA.
Mariusz W SzkudlinskiTrophogen, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-5656-2104
Alan SaghatelianClayton Foundation Laboratory for Peptide Biology Lab, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ron O DrorDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6418-2793
Yifan ChengDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. Yifan.Cheng@ucsf.edu.ORCID http://orcid.org/0000-0001-9535-0369
Aashish ManglikDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. Aashish.Manglik@ucsf.edu.ORCID http://orcid.org/0000-0002-7173-3741
University of California, San Francisco · USSalk Institute for Biological Studies · USStanford University · USHoward Hughes Medical Institute · USTrophogen (United States) · US
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8MThe Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1MThe Discovery of Human Peptide Encoding GenesR01GM102491 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'SHEA, CLODAGH, SAGHATELIAN, ALAN · 2012 to 2025
$5.5MAdvancing cryo-EM technology to address difficult biological questionsR35GM140847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng · 2021 to 2026
$2.1MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MMolecular Mechanisms of Iron HomeostasisDP5OD023048 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANGLIK, AASHISH · 2016 to 2020
$2.0MNovel Long Acting rhTSH Superagonist Analogs for Improved Diagnostic Imaging, Thyroglobulin Stimulation and Therapy of Thyroid Cancer.R44CA224376 · NCI · TROPHOGEN, INC. · PI SZKUDLINSKI, MARIUSZ WALDEMAR, WEINTRAUB, BRUCE DALE · 2018 to 2021
$1.8MDiscovering the mechanism of GPCR-mediated arrestin stimulation to enable effective drug therapiesR01GM127359 · NIGMS · STANFORD UNIVERSITY · PI DROR, RON · 2018 to 2022
$1.5MLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kHoward Hughes Medical InstituteNCI NIH HHS P30 CA014195NCI NIH HHS R44 CA224376NIGMS NIH HHS R01 GM102491NIGMS NIH HHS R01 GM127359NIGMS NIH HHS R35 GM140847NIGMS NIH HHS T32 GM008284NIGMS NIH HHS U24 GM129541NIH HHS DP5 OD023048NIH HHS S10 OD020054NIH HHS S10 OD021741
Abstract
Thyroid hormones are vital in metabolism, growth and development
Indexed as
Cryoelectron MicroscopyImmunoglobulins, Thyroid-StimulatingReceptors, ThyrotropinThyrotropinCell MembraneGraves DiseaseHumansPhospholipidsProtein DomainsReceptors, G-Protein-CoupledRotationImmunoglobulins, Thyroid-StimulatingPhospholipidsReceptors, G-Protein-CoupledReceptors, ThyrotropinThyrotropin
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.