Evidence map›Paper›PMID 35939923›Full record

ArticleJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2022

Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging.

E Dao, M V Clavijo Jordan, K Geraki, A F Martins, S Chirayil, A D Sherry, M J Farquharson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

E DaoDepartment of Physics & Astronomy, McMaster University, 1280 Main St. W., Hamilton, ON L8S 4K1, Canada; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany. Electronic address: daoe@mcmaster.ca.
M V Clavijo JordanAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany.
K GerakiDiamond Light Source, Harwell, Didcot OX11 0DE, United Kingdom; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany.
A F MartinsAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen 72076, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany.
S ChirayilAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany.
A D SherryAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany; Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, United States.
M J FarquharsonCluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076, Germany; School of Interdisciplinary Science, McMaster University, Hamilton, ON L8S 4K1, Canada.
Southwestern Medical Center · USMcMaster University · CADiamond Light Source · GBThe University of Texas at Dallas · US

Funding

Imaging Beta Cell Function in Vivo with Zinc Responsive MRI Contrast AgentsR01DK095416 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SHERRY, DEAN · 2012 to 2021
$3.3M
NIDDK NIH HHS R01 DK095416
6 · The paper itself

Abstract

backgroundContrast agents (CA) are administered in magnetic resonance imaging (MRI) clinical exams to measure tissue perfusion, enhance image contrast between adjacent tissues, or provide additional biochemical information in molecular MRI. The efficacy of a CA is determined by the tissue distribution of the agent and its concentration in the extracellular space of all tissues.

methodsIn this work, micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) was used to examine and characterize a gadolinium-based zinc-sensitive agent (GdL

resultsSignificant Zn and Gd co-localization was observed in both healthy and malignant tissues. In addition, a marked decrease in Zn was found in the lateral lobe of the prostate obtained from mice with PCa.

conclusionWe demonstrate here that µ-SRXRF is a useful tool for monitoring the distribution of several elements including Zn and Gd in animal models of cancer. The optimized procedures for tissue preparation, processing, data collection, and analysis are described.

Indexed as

Prostatic NeoplasmsTrace ElementsAnimalsContrast MediaFluorescenceGadoliniumHumansMagnetic Resonance ImagingMaleMiceSpectrometry, X-Ray EmissionSynchrotronsX-RaysZincContrast MediaGadoliniumTrace ElementsZincContrast agentGadoliniumProstate cancerSynchrotron radiationX-ray fluorescenceZinc

Identifiers

PMID35939923
PMCPMC9940726
OpenAlexW4289597545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.