Evidence map›Paper›PMID 35939387›Full record

ArticleACS synthetic biology2022

Directed Evolution of (

Veronica Saez-Jimenez, Simone Scrima, Matteo Lambrughi, Elena Papaleo, Valeria Mapelli, Martin K M Engqvist, Lisbeth Olsson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Rational design of a highly activeEngineering microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Veronica Saez-JimenezDivision of Industrial Biotechnology, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Simone ScrimaCancer Structural Biology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Matteo LambrughiCancer Structural Biology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Elena PapaleoCancer Structural Biology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.ORCID 0000-0002-7376-5894
Valeria MapelliDivision of Industrial Biotechnology, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.ORCID 0000-0001-8724-3221
Martin K M EngqvistDivision of Systems and Synthetic Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.ORCID 0000-0003-2174-2225
Lisbeth OlssonDivision of Industrial Biotechnology, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Chalmers University of Technology · SEDanish Cancer Society · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathway engineering is commonly employed to improve the production of various metabolites but may incur in bottlenecks due to the low catalytic activity of a particular reaction step. The reduction of 2-oxoadipate to (

Indexed as

AdipatesAlcohol OxidoreductasesMutagenesis2-hydroxyglutarate dehydrogenaseAdipatesadipic acidAlcohol Oxidoreductasesadipic acidprotein engineering(R)-2-hydroxyacid dehydrogenase(R)-2-hydroxyadipaterandom mutagenesissaturation mutagenesis

Identifiers

PMID35939387
PMCPMC9396657
OpenAlexW4290674527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.