Evidence map›Paper›PMID 35939013›Full record

ArticlePhysical review letters2022

Kramers Rate Theory of Pacemaker Dynamics in Noisy Excitable Media.

Zhaoyang Zhang, Gang Hu, Yuhao Zhang, Zhilin Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical review letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhaoyang ZhangDepartment of Physics, School of Physical Science and Technology, Ningbo University, Ningbo, Zhejiang 315211, China.
Gang HuDepartment of Physics, Beijing Normal University, Beijing 100875, China.
Yuhao ZhangDepartment of Physics, School of Physical Science and Technology, Ningbo University, Ningbo, Zhejiang 315211, China.
Zhilin QuDepartment of Medicine, University of California, Los Angeles, California 90095, USA.

Funding

SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
A population-based in silico platform for arrhythmia predictionR01HL134709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R01 HL134709NHLBI NIH HHS R01 HL139829
6 · The paper itself

Abstract

Rhythmic activities, which are usually driven by pacemakers, are common in biological systems. In noisy excitable media, pacemakers are self-organized firing clusters, but the underlying dynamics remains to be elucidated. Here we develop a Kramers rate theory of coupled cells to describe the firing properties of pacemakers and their dependence on coupling strength and system size and dimension. The theory captures accurately the simulation results of tissue models with stochastic Hodgkin-Huxley equations except when transitions from pacemakers to spiral waves occur under weak coupling.

Indexed as

Pacemaker, ArtificialComputer Simulation

Identifiers

PMID35939013
PMCPMC11323706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.