Evidence map›Paper›PMID 35938871›Full record

ArticleJournal of virology2022

TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.

Feixiang Yan, Wei Yang, Xinlu Wang, Guangxia Gao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Feixiang YanCAS Key Laboratory of Infection and Immunity, Institute of Biophysicsgrid.418856.6, Chinese Academy of Sciences, Beijing, China.
Wei YangCAS Key Laboratory of Infection and Immunity, Institute of Biophysicsgrid.418856.6, Chinese Academy of Sciences, Beijing, China.
Xinlu WangCAS Key Laboratory of Infection and Immunity, Institute of Biophysicsgrid.418856.6, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-8887-0550
Guangxia GaoCAS Key Laboratory of Infection and Immunity, Institute of Biophysicsgrid.418856.6, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-5284-0472
Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alphavirus infection induces the expression of type I interferons, which inhibit the viral replication by upregulating the expression of interferon-stimulated genes (ISGs). Identification and mechanistic studies of the antiviral ISGs help to better understand how the host controls viral infection and help to better understand the viral replication process. Here, we report that the ISG product TMEM45B inhibits the replication of Sindbis virus (SINV). TMEM45B is a transmembrane protein that was detected mainly in the

Indexed as

Alphavirus InfectionsInterferon Type IMembrane ProteinsSindbis VirusViral Nonstructural ProteinsAntiviral Restriction FactorsChikungunya virusHost-Pathogen InteractionsHumansRNA, ViralVirus ReplicationAntiviral Restriction FactorsInterferon Type IMembrane ProteinsnsP1 protein, Sindbis virusnsP4 protein, Sindbis virusRNA, ViralTMEM45B protein, humanViral Nonstructural ProteinsSindbis virusTMEM45Bvirus host interaction

Identifiers

PMID35938871
PMCPMC9472651
OpenAlexW4290643909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.