Evidence map›Paper›PMID 35938860›Full record

ArticleMicrobiology spectrum2022

High Prevalence and Persistence of Escherichia coli Strains Producing Shiga Toxin Subtype 2k in Goat Herds.

Xi Yang, Qian Liu, Xiangning Bai, Bin Hu, Deshui Jiang, Hongbo Jiao, Liangmei Lu, Ruyue Fan, Peibin Hou, Andreas Matussek and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Shiga Toxin-ProducingMicroorganisms · 2025
    Review
  3. Interplay between bacterial clones and plasmids in the spread ofOne health (Amsterdam, Netherlands) · 2025
    Article
  4. Hybrid strains of enterotoxigenic/Shiga toxin-producingJournal of medical microbiology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Molecular Characterization ofAnimals : an open access journal from MDPI · 2023
    Article
  10. Article
  11. Prevalence and Implications of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Xi YangState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.ORCID 0000-0001-6776-3676
Qian LiuState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Xiangning BaiState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.ORCID 0000-0002-7085-6723
Bin HuShandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Deshui JiangLanling Center for Disease Control and Prevention, Lanling, Shandong, China.
Hongbo JiaoLanling Center for Disease Control and Prevention, Lanling, Shandong, China.
Liangmei LuLanling Center for Disease Control and Prevention, Lanling, Shandong, China.
Ruyue FanShandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Peibin HouShandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Andreas MatussekDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Yanwen XiongState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.ORCID 0000-0001-6154-6902
Shandong Center for Disease Control and Prevention · CNNational Institute for Communicable Disease Control and Prevention · CNOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shiga toxin (Stx)-producing Escherichia coli (STEC) is a zoonotic pathogen with the ability to cause severe diseases like hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Shiga toxin (Stx) is the key virulence factor in STEC and can be classified into two types, Stx1 and Stx2, and different subtypes. Stx2k is a newly reported Stx2 subtype in E. coli strains from diarrheal patients, animals, and raw meats exclusively in China so far. To understand the reservoir of Stx2k-producing E. coli (Stx2k-STEC), we investigated Stx2k-STEC strains in goat herds and examined their genetic characteristics using whole-genome sequencing. A total of 448 STEC strains were recovered from 2,896 goat fecal samples, and 37.95% (170/448) were Stx2k-STEC. Stx2k-STEC strains of serotype O93:H28 and sequence type 4038 (ST4038) were the most predominant and were detected over several years. Notably, 55% of Stx2k-STEC strains carried the heat-labile toxin (LT)-encoding gene (

Indexed as

Escherichia coli InfectionsEscherichia coli ProteinsShiga-Toxigenic Escherichia coliAnimalsGoatsHumansPhylogenyPrevalenceSheepShiga ToxinEscherichia coli ProteinsShiga ToxinEscherichia coliShiga toxin (Stx)Stx2k-converting prophageStx2k subtypewhole-genome sequencing

Identifiers

PMID35938860
PMCPMC9431244
OpenAlexW4290644172

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.