Evidence map›Paper›PMID 35938813›Full record

ArticleMicrobiology spectrum2022

CRISPR-Cas in Acinetobacter baumannii Contributes to Antibiotic Susceptibility by Targeting Endogenous

Yuhang Wang, Jie Yang, Xiaoli Sun, Mengying Li, Pengyu Zhang, Zhongtian Zhu, Hongmei Jiao, Tingting Guo, Guocai Li

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Colistin Resistance in Bacteria: Current Updates on Mechanism of Action and Combating Strategies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Threat and Control ofFoods (Basel, Switzerland) · 2025
    Review
  7. Review
  8. Microbiology spectrum · 2025
    Article
  9. Carbapenem Resistance inMicroorganisms · 2025
    Review
  10. Article
  11. Review
  12. Whole-genome sequencing ofMicrobial genomics · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Endogenous Type I-C CRISPR-Cas system ofFrontiers in microbiology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuhang WangDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.ORCID 0000-0002-5902-8310
Jie YangDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.
Xiaoli SunJiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Yangzhou, PR China.
Mengying LiDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.
Pengyu ZhangDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.
Zhongtian ZhuDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.
Hongmei JiaoDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.
Tingting GuoDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.
Guocai LiDepartment of Microbiology, Institute of Translational Medicine, Medical College, Yangzhou Universitygrid.268415.c, Yangzhou, PR China.ORCID 0000-0002-3971-7434
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acinetobacter baumannii is a well-known human opportunistic pathogen in nosocomial infections, and the emergence of multidrug-resistant Acinetobacter baumannii has become a complex problem for clinical anti-infective treatments. The ways this organism obtains multidrug resistance phenotype include horizontal gene transfer and other mechanisms, such as altered targets, decreased permeability, increased enzyme production, overexpression of efflux pumps, metabolic changes, and biofilm formation. A CRISPR-Cas system generally consists of a CRISPR array and one or more operons of

Indexed as

Acinetobacter baumanniiCRISPR-Associated ProteinsAnti-Bacterial AgentsBacteriaBacterial ProteinsBiofilmsCRISPR-Cas SystemsDrug Resistance, Multiple, BacterialHumansReactive Oxygen SpeciesAnti-Bacterial AgentsBacterial ProteinsCRISPR-Associated ProteinsReactive Oxygen SpeciesabaIAcinetobacter baumanniiantibiotic susceptibilityCRISPR-Cas

Identifiers

PMID35938813
PMCPMC9430643
OpenAlexW4290644155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.